OBJECTIVES: Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with
increasing disability, reduced quality of life and substantial costs (as a result of both …

Background: To support decision-making in aortic valve replacement in children and adults,
we provide a comprehensive overview of outcome after the Ross procedure. Methods and …

Discrete event simulation (DES) is a form of computer-based modeling that provides an
intuitive and flexible approach to representing complex systems. It has been used in a wide …

In financially constrained health systems across the world, increasing emphasis is being
placed on the ability to demonstrate that health care interventions are not only effective, but …

Abstract Models for the economic evaluation of health technologies provide valuable
information to decision makers. The choice of model structure is rarely discussed in …

Objectives To assess the long term clinical and cost effectiveness of the diabetes education
and self management for ongoing and newly diagnosed (DESMOND) intervention …

This paper describes the key principles of why an assessment of uncertainty and its
consequences are critical for the types of decisions that a body such as the UK National …

Health economic evaluations have recently become an important part of the clinical and
medical research process and have built upon more advanced statistical decision-theoretic …

Background Allocation of deceased-donor livers to patients with chronic liver failure is
improved by prioritising patients by 5-year liver transplantation survival benefit. The …

Accounting for uncertainty is now a standard part of decision-analytic modeling and is
recommended by many health technology agencies and published guidelines. However, the …