Design in synthetic biology is typically goal oriented, aiming to repurpose or optimize
existing biological functions, augmenting biology with new-to-nature capabilities, or creating …

AI-enabled synthetic biology has tremendous potential but also significantly increases
biorisks and brings about a new set of dual use concerns. The picture is complicated given …

Abstract The Ser/Leu-swapped genetic code can act as a genetic firewall, mitigating
biohazard risks arising from horizontal gene transfer in genetically modified organisms. Our …

B. anthracis is one of the most often weaponized pathogens. States had it in their
bioweapons programs and criminals and terrorists have used or attempted to use it. This …

Background Smallpox was a major source of human mortality until its eradication, but the
threat from orthopox viruses has not disappeared. Since the eradication of smallpox and the …

DNA sequences of nearly any desired composition, length, and function can be synthesized
to alter the biology of an organism for purposes ranging from the bioproduction of …

Data science is playing an increasingly important role in the design and analysis of
engineered biology. This has been fueled by the development of high-throughput methods …

The threat landscape of biological hazards with the evolution of AI presents challenges.
While AI promises innovative solutions, concerns arise about its misuse in the creation of …

Biology in the 21st century presents us with tremendous potential to harness the natural
world to address key global challenges. In particular, our ability to engineer new …

Synthetic biology holds immense promise to tackle key problems in resource use,
environmental remediation, and human health care. However, comprehensive safety …