[HTML][HTML] Alzheimer's disease pathophysiology in the retina

BP Gaire, Y Koronyo, DT Fuchs, H Shi… - Progress in Retinal and …, 2024 - Elsevier
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …

The use of optical coherence tomography in neurology: a review

JS Xie, L Donaldson, E Margolin - Brain, 2022 - academic.oup.com
Optical coherence tomography is a non-invasive, cost-efficient technique that provides high-
resolution in vivo imaging of retinal tissue. The peripapillary retinal nerve fibre layer and …

Retinal pathological features and proteome signatures of Alzheimer's disease

Y Koronyo, A Rentsendorj, N Mirzaei, GC Regis… - Acta …, 2023 - Springer
Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory
retina. However, their exact nature and topographical distribution, particularly in the early …

The gut microbiota in retinal diseases

MA Bringer, PH Gabrielle, AM Bron… - Experimental Eye …, 2022 - Elsevier
The gut microbiota is a complex ecosystem that inhabits the gastrointestinal tract and
consists of archaea, fungi, viruses, and bacteria, with bacteria being dominant. From birth …

Association between retinal layer thickness and cognitive decline in older adults

HM Kim, JW Han, YJ Park, JB Bae, SJ Woo… - JAMA …, 2022 - jamanetwork.com
Importance Retinal layer thickness is hypothesized to be related to cognitive function in
patients with mild cognitive impairment (MCI) and Alzheimer disease (AD). However …

[HTML][HTML] The retina: A window in which to view the pathogenesis of Alzheimer's disease

J Zhang, L Shi, Y Shen - Ageing Research Reviews, 2022 - Elsevier
Alzheimer's disease (AD) is the most familiar type of dementia affecting elderly populations
worldwide. Studies of AD patients and AD transgenic mice have revealed alterations in the …

Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions

J Alber, F Bouwman, J den Haan… - Alzheimer's & …, 2024 - Wiley Online Library
There is emerging evidence that amyloid beta protein (Aβ) and tau‐related lesions in the
retina are associated with Alzheimer's disease (AD). Aβ and hyperphosphorylated (p)‐tau …

OCT Imaging in Murine Models of Alzheimer's Disease in a Systematic Review: Findings, Methodology and Future Perspectives

L Sánchez-Puebla, I López-Cuenca, E Salobrar-García… - Biomedicines, 2024 - mdpi.com
The murine models of Alzheimer's disease (AD) have advanced our understanding of the
pathophysiology. In vivo studies of the retina using optical coherence tomography (OCT) …

Salivary exosomes in health and disease: future prospects in the eye

A Liu, B Hefley, P Escandon, SE Nicholas… - International journal of …, 2023 - mdpi.com
Exosomes are a group of vesicles that package and transport DNA, RNA, proteins, and
lipids to recipient cells. They can be derived from blood, saliva, urine, and/or other biological …

Retinal imaging biomarkers of Alzheimer's disease: A systematic review and meta‐analysis of studies using brain amyloid beta status for case definition

G Ashraf, M McGuinness, MA Khan… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction We performed a systematic review and meta‐analysis of the association
between retinal imaging parameters and Alzheimer's disease (AD). Methods PubMed …