Arynes are among the most active organic intermediates and have found numerous
applications in expeditious preparation of substituted arenes. In the past 20 years, chemists …

The synthesis of biaryls from benzyne intermediates offers an alternative strategy to
conventional metal-catalyzed cross-coupling approaches. The concept is as old as benzyne …

The pyridine heterocycle continues to play a vital role in the development of human
medicines. More than 100 currently marketed drugs contain this privileged unit, which …

A palladium-catalyzed domino aminopalladation/CH functionalization sequence has been
developed, and provides access to functionalized phenanthridines and isoquinolines. The …

Arynes are neutral intermediates in which two adjacent atoms of an aromatic ring lack
substituents, thus leaving two atomic orbitals (perpendicular to the aromatic x system) to …

Many methods have been developed for generating benzyne. Convenient and reliable
precursors extensively studied so far involve benzenediazonium-2-carboxylate and o …

A palladium-catalyzed cross-coupling reaction of aryl halides with 2-chlorobenzoic acids
has been developed. The reaction forms C (sp3), C (sp2)-palladacycles through C (sp3)–H …

A mild, general, and transition-metal-free protocol for the synthesis of 9, 10-
dihydrophenanthrenes is reported. The aryne generated by the fluoride-induced 1, 2 …

Transition-metal-mediated cycloadditions of alkynes and alkenes serve as a powerful
strategy to construct a wide range of compounds, since complexation of the metal center to …

A facile synthesis of natural and unnatural arylnaphthalenes has been demonstrated via the
unprecedented palladium-promoted [2+ 2+ 2] cocyclization of arynes and unsymmetrical …