Abstract Matrix metalloproteinase (MMP)-2 belongs to a family of zinc-dependent proteases
which are best known for their ability to proteolyse extracellular matrix proteins throughout …

Background: Cardiac arrhythmias represent a significant problem globally, leading to
cerebrovascular accidents, myocardial infarction, and sudden cardiac death. There is …

Bone remodeling is a very complex process. Homocysteine (Hcy) is known to modulate this
process via several known mechanisms such as increase in osteoclast activity, decrease in …

Cardiomyocyte N-methyl-d-aspartate receptor-1 (NMDA-R1) activation induces
mitochondrial dysfunction. Matrix metalloproteinase protease (MMP) induction is a negative …

Purpose.: In the pathogenesis of diabetic retinopathy, retinal mitochondria become
dysfunctional, their DNA is damaged, and capillary cells undergo accelerated apoptosis …

The NO/ONOO-cycle is a primarily local, biochemical vicious cycle mechanism, centered on
elevated peroxynitrite and oxidative stress, but also involving 10 additional elements: NF-κB …

Cardiac muscle is unique because it contracts ceaselessly throughout the life and is highly
resistant to fatigue. The marvelous nature of the cardiac muscle is attributed to its matrix that …

Myocardial ischemia affects mitochondrial function leading to ionic imbalance and
susceptibility to ventricular fibrillation. Trimetazidine (TMZ), a metabolic agent, is clinically …

OBJECTIVE: We have previously shown that homocysteine (Hcy) induces
phosphatidylserine (PS) exposure, apoptosis and necrosis in human endothelial cells. Since …

Remodeling by its very nature implied synthesis and degradation of extracellular matrix
(ECM) proteins. Although oxidative stress, matrix metalloproteinase (MMP) and tissue …