[HTML][HTML] Hydrogen peroxide sensing, signaling and regulation of transcription factors
The regulatory mechanisms by which hydrogen peroxide (H 2 O 2) modulates the activity of
transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and …
transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and …
Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders
V Calabrese, C Cornelius… - Antioxidants & redox …, 2010 - liebertpub.com
Despite the capacity of chaperones and other homeostatic components to restore folding
equilibrium, cells appear poorly adapted for chronic oxidative stress that increases in cancer …
equilibrium, cells appear poorly adapted for chronic oxidative stress that increases in cancer …
[HTML][HTML] Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity
V Calabrese, C Cornelius, AT Dinkova-Kostova… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Modulation of endogenous cellular defense mechanisms represents an innovative approach
to therapeutic intervention in diseases causing chronic tissue damage, such as in …
to therapeutic intervention in diseases causing chronic tissue damage, such as in …
Regulation of the mammalian heat shock factor 1
S Dayalan Naidu, AT Dinkova‐Kostova - The FEBS journal, 2017 - Wiley Online Library
Living organisms are endowed with the capability to tackle various forms of cellular stress
due to the presence of molecular chaperone machinery complexes that are ubiquitous …
due to the presence of molecular chaperone machinery complexes that are ubiquitous …
Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids
E Kansanen, HK Jyrkkänen, AL Levonen - Free Radical Biology and …, 2012 - Elsevier
Unsaturated fatty acids are prone to radical reactions that occur in biological situations
where extensive formation of reactive oxygen and nitrogen species (ROS and RNS) takes …
where extensive formation of reactive oxygen and nitrogen species (ROS and RNS) takes …
Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity
V Calabrese, C Cornelius, S Cuzzocrea… - Molecular aspects of …, 2011 - Elsevier
Understanding mechanisms of aging and determinants of life span will help to reduce age-
related morbidity and facilitate healthy aging. Average lifespan has increased over the last …
related morbidity and facilitate healthy aging. Average lifespan has increased over the last …
Molecular mechanism of thermosensory function of human heat shock transcription factor Hsf1
N Hentze, L Le Breton, J Wiesner, G Kempf, MP Mayer - elife, 2016 - elifesciences.org
The heat shock response is a universal homeostatic cell autonomous reaction of organisms
to cope with adverse environmental conditions. In mammalian cells, this response is …
to cope with adverse environmental conditions. In mammalian cells, this response is …
HIF1, HSF1, and NRF2: oxidant-responsive trio raising cellular defenses and engaging immune system
AM Cyran, A Zhitkovich - Chemical research in toxicology, 2022 - ACS Publications
Cellular homeostasis is continuously challenged by damage from reactive oxygen species
(ROS) and numerous reactive electrophiles. Human cells contain various protective systems …
(ROS) and numerous reactive electrophiles. Human cells contain various protective systems …
Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection
SD Naidu, RV Kostov, AT Dinkova-Kostova - Trends in pharmacological …, 2015 - cell.com
Transcription factors heat shock factor (Hsf) 1 and nuclear factor-erythroid 2 p45-related
factor (Nrf) 2 are critical for adaptation and survival. Each is maintained at low basal levels …
factor (Nrf) 2 are critical for adaptation and survival. Each is maintained at low basal levels …
Structure of human heat-shock transcription factor 1 in complex with DNA
T Neudegger, J Verghese, M Hayer-Hartl… - Nature structural & …, 2016 - nature.com
Heat-shock transcription factor 1 (HSF1) has a central role in mediating the protective
response to protein conformational stresses in eukaryotes. HSF1 consists of an N-terminal …
response to protein conformational stresses in eukaryotes. HSF1 consists of an N-terminal …