The regulatory mechanisms by which hydrogen peroxide (H 2 O 2) modulates the activity of
transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and …

Despite the capacity of chaperones and other homeostatic components to restore folding
equilibrium, cells appear poorly adapted for chronic oxidative stress that increases in cancer …

Modulation of endogenous cellular defense mechanisms represents an innovative approach
to therapeutic intervention in diseases causing chronic tissue damage, such as in …

Living organisms are endowed with the capability to tackle various forms of cellular stress
due to the presence of molecular chaperone machinery complexes that are ubiquitous …

Unsaturated fatty acids are prone to radical reactions that occur in biological situations
where extensive formation of reactive oxygen and nitrogen species (ROS and RNS) takes …

Understanding mechanisms of aging and determinants of life span will help to reduce age-
related morbidity and facilitate healthy aging. Average lifespan has increased over the last …

The heat shock response is a universal homeostatic cell autonomous reaction of organisms
to cope with adverse environmental conditions. In mammalian cells, this response is …

Cellular homeostasis is continuously challenged by damage from reactive oxygen species
(ROS) and numerous reactive electrophiles. Human cells contain various protective systems …

Transcription factors heat shock factor (Hsf) 1 and nuclear factor-erythroid 2 p45-related
factor (Nrf) 2 are critical for adaptation and survival. Each is maintained at low basal levels …

Heat-shock transcription factor 1 (HSF1) has a central role in mediating the protective
response to protein conformational stresses in eukaryotes. HSF1 consists of an N-terminal …