Recent advances in single-cell technologies have enabled high-throughput molecular
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …

Abstract Assay of Transposase Accessible Chromatin sequencing (ATAC-seq) is widely
used in studying chromatin biology, but a comprehensive review of the analysis tools has …

Neutrophils are increasingly recognized as key players in the tumor immune response and
are associated with poor clinical outcomes. Despite recent advances characterizing the …

In this study, we detail a novel approach that combines bacterial fitness fluorescent reporter
strains with scRNA-seq to simultaneously acquire the host transcriptome, surface marker …

Regulatory T (Treg) cells suppress effective antitumor immunity in tumor-bearing hosts,
thereby becoming promising targets in cancer immunotherapy. Despite the importance of …

Chromatin accessibility, or the physical access to chromatinized DNA, is a widely studied
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …

Single-cell assay for transposase-accessible chromatin by sequencing (scATAC-seq) has
emerged as a powerful tool for dissecting regulatory landscapes and cellular heterogeneity …

Housekeeping (HK) genes are constitutively expressed genes that are required for the
maintenance of basic cellular functions. Despite their importance in the calibration of gene …

Disrupted sleep-wake and molecular circadian rhythms are a feature of aging associated
with metabolic disease and reduced levels of NAD+, yet whether changes in nucleotide …

The mammalian cerebrum performs high-level sensory perception, motor control and
cognitive functions through highly specialized cortical and subcortical structures. Recent …