The mycobacterial cell envelope—a moving target

CL Dulberger, EJ Rubin, CC Boutte - Nature Reviews Microbiology, 2020 - nature.com
Mycobacterium tuberculosis, the leading cause of death due to infection, has a dynamic and
immunomodulatory cell envelope. The cell envelope structurally and functionally varies …

Pathogenicity and virulence of Mycobacterium tuberculosis

KC Rahlwes, BRS Dias, PC Campos… - Virulence, 2023 - Taylor & Francis
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

[HTML][HTML] Consequences of genomic diversity in Mycobacterium tuberculosis

M Coscolla, S Gagneux - Seminars in immunology, 2014 - Elsevier
The causative agent of human tuberculosis, Mycobacterium tuberculosis complex (MTBC),
comprises seven phylogenetically distinct lineages associated with different geographical …

[HTML][HTML] Genome-wide association studies of global Mycobacterium tuberculosis resistance to 13 antimicrobials in 10,228 genomes identify new resistance …

CRyPTIC Consortium - PLoS biology, 2022 - journals.plos.org
The emergence of drug-resistant tuberculosis is a major global public health concern that
threatens the ability to control the disease. Whole-genome sequencing as a tool to rapidly …

[HTML][HTML] Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance

ES Kavvas, E Catoiu, N Mih, JT Yurkovich… - Nature …, 2018 - nature.com
Mycobacterium tuberculosis is a serious human pathogen threat exhibiting complex
evolution of antimicrobial resistance (AMR). Accordingly, the many publicly available …

How sisters grow apart: mycobacterial growth and division

KJ Kieser, EJ Rubin - Nature Reviews Microbiology, 2014 - nature.com
Mycobacterium tuberculosis, which is the aetiological agent of tuberculosis, owes much of its
success as a pathogen to its unique cell wall and unusual mechanism of growth, which …

Eukaryote-like serine/threonine kinases and phosphatases in bacteria

SFF Pereira, L Goss, J Dworkin - Microbiology and Molecular …, 2011 - Am Soc Microbiol
Genomic studies have revealed the presence of Ser/Thr kinases and phosphatases in many
bacterial species, although their physiological roles have largely been unclear. Here we …

The cell envelope glycoconjugates of Mycobacterium tuberculosis

SK Angala, JM Belardinelli, E Huc-Claustre… - Critical reviews in …, 2014 - Taylor & Francis
Tuberculosis (TB) remains the second most common cause of death due to a single
infectious agent. The cell envelope of Mycobacterium tuberculosis (Mtb), the causative agent …

Division and cell envelope regulation by Ser/Thr phosphorylation: Mycobacterium shows the way

V Molle, L Kremer - Molecular microbiology, 2010 - Wiley Online Library
Mycobacterium tuberculosis (M. tb) has a complex lifestyle in different environments and
involving several developmental stages. The success of M. tb results from its remarkable …

[图书][B] Bacterial resistance to antimicrobials

RG Wax, K Lewis, AA Salyers, H Taber - 2007 - taylorfrancis.com
The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available
antibiotics, and requires new approaches to antibiotic discovery and development …