Many inner ear disorders cannot be adequately treated by systemic drug delivery. A blood-
cochlear barrier exists, similar physiologically to the blood-brain barrier, which limits the …

Introduction: Advances in molecular biology and in the basic understanding of the
mechanisms associated with sensorineural hearing loss and other diseases of the inner ear …

The anatomical and pharmacological inaccessibility of the inner ear is a major challenge in
drug-based treatment of auditory disorders. This also makes pharmacokinetic …

The goal of this study was to develop an appropriate methodology to apply drugs
quantitatively to the perilymph of the ear. Intratympanic applications of drugs to the inner ear …

Loss of balance is often due to loss of vestibular hair cells. In mammals, regeneration of
functional hair cells in the mature sensory epithelium is limited; therefore, loss of sensory …

Hearing aids or cochlear implants constitute almost exclusively the treatment options
currently available to patients suffering from sensorineural hearing loss and related …

One of the major challenges in treatment of auditory disorders is that many therapeutic
compounds are toxic when delivered systemically. Local intracochlear delivery methods are …

Optimal methods of inner ear drug delivery will depend on toxicity, therapeutic dose range,
and characteristics of the agent to be delivered. Advanced therapy development will likely …

Abstract Objectives/Hypothesis: To evaluate the ability of the Ad28. gfap. atoh1 to promote
hair cell regeneration and hearing recovery in cochlea injured with kanamycin and …

Over 450 million people worldwide suffer from hearing loss, leading to an estimated
economic burden of∼ $750 billion. The past decade has seen significant advances in the …