Genomes have complex three-dimensional structures. High-resolution population-based
biochemical studies over the last decade have painted a mostly static picture of the genome …

As phosphorus is one of the most limiting nutrients in many natural and agricultural
ecosystems, plants have evolved strategies that cope with its scarcity. Genetic approaches …

Eukaryotic genomes are packaged into high-order chromatin structures organized in
discrete territories inside the cell nucleus, which is surrounded by the nuclear envelope …

Topologically associating domains (TADs) were recently identified as fundamental units of
three-dimensional eukaryotic genomic organization, although our knowledge of the …

Genome organization can regulate gene expression and promote cell fate transitions. The
differentiation of germline stem cells (GSCs) to oocytes in Drosophila involves changes in …

The DNA in many organisms, including humans, is shown to be organized in topologically
associating domains (TADs). In Drosophila, several architectural proteins are enriched at …

Hox gene clusters encode transcription factors that drive regional specialization during
animal development: for example the Hox factor Ubx is expressed in the insect metathoracic …

Topologically associating domains (TADs) are thought to play an important role in
preventing gene misexpression by spatially constraining enhancer–promoter contacts. The …

Brugada syndrome (BrS) is an inherited electrical heart disease associated with a high risk
of sudden cardiac death (SCD). The genetic characterization of BrS has always been …

Widespread cotranscriptional splicing has been demonstrated from yeast to human.
However, most studies to date addressing the kinetics of splicing relative to transcription …