[HTML][HTML] Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations

D Primorac, V Molnar, E Rod, Ž Jeleč, F Čukelj… - Genes, 2020 - mdpi.com
Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …

[HTML][HTML] Benefits and mechanisms of exercise training for knee osteoarthritis

CY Zeng, ZR Zhang, ZM Tang, FZ Hua - Frontiers in physiology, 2021 - frontiersin.org
Knee osteoarthritis is a chronic degenerative disease. Cartilage and subchondral bone
degeneration, as well as synovitis, are the main pathological changes associated with knee …

Knee osteoarthritis has doubled in prevalence since the mid-20th century

IJ Wallace, S Worthington, DT Felson… - Proceedings of the …, 2017 - National Acad Sciences
Knee osteoarthritis (OA) is believed to be highly prevalent today because of recent
increases in life expectancy and body mass index (BMI), but this assumption has not been …

Exercise as medicine–evidence for prescribing exercise as therapy in 26 different chronic diseases

BK Pedersen, B Saltin - … journal of medicine & science in sports, 2015 - Wiley Online Library
This review provides the reader with the up‐to‐date evidence‐based basis for prescribing
exercise as medicine in the treatment of 26 different diseases: psychiatric diseases …

[HTML][HTML] Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis

D Kang, J Lee, J Jung, BA Carlson, MJ Chang… - Nature …, 2022 - nature.com
Aging and mechanical overload are prominent risk factors for osteoarthritis (OA), which lead
to an imbalance in redox homeostasis. The resulting state of oxidative stress drives the …

[HTML][HTML] Knee extensor muscle weakness is a risk factor for development of knee osteoarthritis. A systematic review and meta-analysis

BE Øiestad, CB Juhl, I Eitzen, JB Thorlund - Osteoarthritis and cartilage, 2015 - Elsevier
The objective of this study was to perform a systematic review and meta-analysis on the
association between knee extensor muscle weakness and the risk of developing knee …

Osteolysis around total knee arthroplasty: a review of pathogenetic mechanisms

J Gallo, SB Goodman, YT Konttinen, MA Wimmer… - Acta biomaterialia, 2013 - Elsevier
Aseptic loosening and other wear-related complications are some of the most frequent late
reasons for revision of total knee arthroplasty (TKA). Periprosthetic osteolysis (PPOL) pre …

Establishing outcome measures in early knee osteoarthritis

CA Emery, JL Whittaker, A Mahmoudian… - Nature Reviews …, 2019 - nature.com
The classification and monitoring of individuals with early knee osteoarthritis (OA) are
important considerations for the design and evaluation of therapeutic interventions and …

Post-traumatic osteoarthritis: from mouse models to clinical trials

CB Little, DJ Hunter - Nature Reviews Rheumatology, 2013 - nature.com
Osteoarthritis (OA), the most common of all arthropathies, is a leading cause of disability and
has a large (and growing) worldwide socioeconomic cost. Despite its burgeoning …

Biological aspects of early osteoarthritis

H Madry, FP Luyten, A Facchini - Knee surgery, sports traumatology …, 2012 - Springer
Purpose Early OA primarily affects articular cartilage and involves the entire joint, including
the subchondral bone, synovial membrane, menisci and periarticular structures. The aim of …