Fine-tuning cellular physiology in response to intracellular and environmental cues requires
precise temporal and spatial control of gene expression. High-resolution imaging …

Optical microscopy has for centuries been a key tool to study living cells with minimum
invasiveness. The advent of single molecule techniques over the past two decades has …

Uncovering the mechanisms of virus infection and assembly is crucial for preventing the
spread of viruses and treating viral disease. The technique of single-virus tracking (SVT) …

The spatial regulation of protein translation is an efficient way to create functional and
structural asymmetries in cells. Recent research has furthered our understanding of how …

Green fluorescent protein (GFP) from the jellyfish Aequorea victoria and its homologs from
diverse marine animals are widely used as universal genetically encoded fluorescent labels …

Messenger ribonucleoprotein (mRNP) granules are dynamic, self-assembling structures that
harbor non-translating mRNAs bound by various proteins that regulate mRNA translation …

The localization of mRNAs to subcellular compartments provides a mechanism for
regulating gene expression with exquisite temporal and spatial control. Recent studies …

Fluorescence image co-localization analysis is widely utilized to suggest biomolecular
interaction. However, there exists some confusion as to its correct implementation and …

Live-cell imaging of mRNA yields important insights into gene expression, but it has
generally been limited to the labeling of one RNA species and has never been used to count …

The localization of RNAs critically contributes to many important cellular processes in an
organism, such as the establishment of polarity, asymmetric division and migration during …