Perspectives on triple-negative breast cancer: current treatment strategies, unmet needs, and potential targets for future therapies
GK Gupta, AL Collier, D Lee, RA Hoefer, V Zheleva… - Cancers, 2020 - mdpi.com
Triple-negative breast cancer (TNBC), characterized by the absence or low expression of
estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor …
estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor …
Anticancer or carcinogenic? The role of estrogen receptor β in breast cancer progression
K Shen, H Yu, B Xie, Q Meng, C Dong, K Shen… - Pharmacology & …, 2023 - Elsevier
Estrogen receptor β (ERβ) is closely related to breast cancer (BC) progression. Traditional
concepts regard ERβ as a tumor suppressor. As studies show the carcinogenic effect of …
concepts regard ERβ as a tumor suppressor. As studies show the carcinogenic effect of …
Estrogen actions in triple-negative breast cancer
O Treeck, S Schüler-Toprak, O Ortmann - Cells, 2020 - mdpi.com
Triple-negative breast cancer (TNBC) lacks estrogen receptor (ER) α, but the expression of
estrogen receptors ERβ and G protein-coupled estrogen receptor 1 (GPER-1) is able to …
estrogen receptors ERβ and G protein-coupled estrogen receptor 1 (GPER-1) is able to …
Drivers and suppressors of triple-negative breast cancer
W Wu, M Warner, L Wang, WW He… - Proceedings of the …, 2021 - National Acad Sciences
To identify regulators of triple-negative breast cancer (TNBC), gene expression profiles of
malignant parts of TNBC (mTNBC) and normal adjacent (nadj) parts of the same breasts …
malignant parts of TNBC (mTNBC) and normal adjacent (nadj) parts of the same breasts …
Tamoxifen induces apoptosis through cancerous inhibitor of protein phosphatase 2A–dependent phospho-Akt inactivation in estrogen receptor–negative human …
Introduction Tamoxifen, a selective estrogen receptor (ER) modulator, may affect cancer cell
survival through mechanisms other than ER antagonism. In the present study, we tested the …
survival through mechanisms other than ER antagonism. In the present study, we tested the …
The role of estrogen receptor beta in breast cancer
Y Zhou, X Liu - Biomarker research, 2020 - Springer
Breast cancer, a malignant tumor originating from mammary epithelial tissue, is the most
common cancer among women worldwide. Challenges facing the diagnosis and treatment …
common cancer among women worldwide. Challenges facing the diagnosis and treatment …
[HTML][HTML] Estrogen receptor-beta is a potential target for triple negative breast cancer treatment
D Austin, N Hamilton, Y Elshimali, R Pietras, Y Wu… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Triple Negative breast cancer (TNBC) is a subtype of breast cancer that lacks the expression
of estrogen receptor (ER), progesterone receptor, and human epidermal growth factor …
of estrogen receptor (ER), progesterone receptor, and human epidermal growth factor …
Estrogens and progestogens in triple negative breast cancer: do they harm?
M van Barele, BAM Heemskerk-Gerritsen, YV Louwers… - Cancers, 2021 - mdpi.com
Simple Summary Young women treated for breast cancer may experience early
menopause, which can negatively impact quality of life. The usual treatment for early …
menopause, which can negatively impact quality of life. The usual treatment for early …
Extracellular RNA in a single droplet of human serum reflects physiologic and disease states
Extracellular RNAs (exRNAs) are present in human serum. It remains unclear to what extent
these circulating exRNAs may reflect human physiologic and disease states. Here, we …
these circulating exRNAs may reflect human physiologic and disease states. Here, we …
Estrogen receptor beta 1: a potential therapeutic target for female triple negative breast cancer
P Dey, A Wang, Y Ziegler, S Kumar, S Yan… - …, 2022 - academic.oup.com
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer
characterized by the absence of estrogen receptor alpha, progesterone receptor, and HER2 …
characterized by the absence of estrogen receptor alpha, progesterone receptor, and HER2 …