Perspectives on triple-negative breast cancer: current treatment strategies, unmet needs, and potential targets for future therapies

GK Gupta, AL Collier, D Lee, RA Hoefer, V Zheleva… - Cancers, 2020 - mdpi.com
Triple-negative breast cancer (TNBC), characterized by the absence or low expression of
estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor …

Anticancer or carcinogenic? The role of estrogen receptor β in breast cancer progression

K Shen, H Yu, B Xie, Q Meng, C Dong, K Shen… - Pharmacology & …, 2023 - Elsevier
Estrogen receptor β (ERβ) is closely related to breast cancer (BC) progression. Traditional
concepts regard ERβ as a tumor suppressor. As studies show the carcinogenic effect of …

Estrogen actions in triple-negative breast cancer

O Treeck, S Schüler-Toprak, O Ortmann - Cells, 2020 - mdpi.com
Triple-negative breast cancer (TNBC) lacks estrogen receptor (ER) α, but the expression of
estrogen receptors ERβ and G protein-coupled estrogen receptor 1 (GPER-1) is able to …

Drivers and suppressors of triple-negative breast cancer

W Wu, M Warner, L Wang, WW He… - Proceedings of the …, 2021 - National Acad Sciences
To identify regulators of triple-negative breast cancer (TNBC), gene expression profiles of
malignant parts of TNBC (mTNBC) and normal adjacent (nadj) parts of the same breasts …

Tamoxifen induces apoptosis through cancerous inhibitor of protein phosphatase 2A–dependent phospho-Akt inactivation in estrogen receptor–negative human …

CY Liu, MH Hung, DS Wang, PY Chu, JC Su… - Breast cancer …, 2014 - Springer
Introduction Tamoxifen, a selective estrogen receptor (ER) modulator, may affect cancer cell
survival through mechanisms other than ER antagonism. In the present study, we tested the …

The role of estrogen receptor beta in breast cancer

Y Zhou, X Liu - Biomarker research, 2020 - Springer
Breast cancer, a malignant tumor originating from mammary epithelial tissue, is the most
common cancer among women worldwide. Challenges facing the diagnosis and treatment …

[HTML][HTML] Estrogen receptor-beta is a potential target for triple negative breast cancer treatment

D Austin, N Hamilton, Y Elshimali, R Pietras, Y Wu… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Triple Negative breast cancer (TNBC) is a subtype of breast cancer that lacks the expression
of estrogen receptor (ER), progesterone receptor, and human epidermal growth factor …

Estrogens and progestogens in triple negative breast cancer: do they harm?

M van Barele, BAM Heemskerk-Gerritsen, YV Louwers… - Cancers, 2021 - mdpi.com
Simple Summary Young women treated for breast cancer may experience early
menopause, which can negatively impact quality of life. The usual treatment for early …

Extracellular RNA in a single droplet of human serum reflects physiologic and disease states

Z Zhou, Q Wu, Z Yan, H Zheng… - Proceedings of the …, 2019 - National Acad Sciences
Extracellular RNAs (exRNAs) are present in human serum. It remains unclear to what extent
these circulating exRNAs may reflect human physiologic and disease states. Here, we …

Estrogen receptor beta 1: a potential therapeutic target for female triple negative breast cancer

P Dey, A Wang, Y Ziegler, S Kumar, S Yan… - …, 2022 - academic.oup.com
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer
characterized by the absence of estrogen receptor alpha, progesterone receptor, and HER2 …