Human glioblastoma arises from subventricular zone cells with low-level driver mutations
Glioblastoma (GBM) is a devastating and incurable brain tumour, with a median overall
survival of fifteen months,. Identifying the cell of origin that harbours mutations that drive …
survival of fifteen months,. Identifying the cell of origin that harbours mutations that drive …
Leptomeningeal spread in glioblastoma: diagnostic and therapeutic challenges
Background Glioblastoma (GBM) is the most common and aggressive primary malignant
brain tumor. Leptomeningeal spread (LMS) is a severe complication of GBM, raising …
brain tumor. Leptomeningeal spread (LMS) is a severe complication of GBM, raising …
Recent advances in oncolytic virotherapy and immunotherapy for glioblastoma: a glimmer of hope in the search for an effective therapy?
AA Stepanenko, VP Chekhonin - Cancers, 2018 - mdpi.com
To date, no targeted drugs, antibodies or combinations of chemotherapeutics have been
demonstrated to be more efficient than temozolomide, or to increase efficacy of standard …
demonstrated to be more efficient than temozolomide, or to increase efficacy of standard …
Progress toward long-term survivors of glioblastoma
Objective To identify the frequency and characteristics of long-term survivors of
glioblastoma. Patients and Methods Using all cases of glioblastoma with histopathological …
glioblastoma. Patients and Methods Using all cases of glioblastoma with histopathological …
Etomoxir, a carnitine palmitoyltransferase 1 inhibitor, combined with temozolomide reduces stemness and invasiveness in patient-derived glioblastoma tumorspheres
Introduction The importance of fatty acid oxidation (FAO) in the bioenergetics of glioblastoma
(GBM) is being realized. Etomoxir (ETO), a carnitine palmitoyltransferase 1 (CPT1) inhibitor …
(GBM) is being realized. Etomoxir (ETO), a carnitine palmitoyltransferase 1 (CPT1) inhibitor …
Survival benefit of lobectomy over gross-total resection without lobectomy in cases of glioblastoma in the noneloquent area: a retrospective study
TH Roh, SG Kang, JH Moon, KS Sung, HH Park… - Journal of …, 2019 - thejns.org
OBJECTIVE Following resection of glioblastoma (GBM), microscopic remnants of the GBM
tumor remaining in nearby tissue cause tumor recurrence more often than for other types of …
tumor remaining in nearby tissue cause tumor recurrence more often than for other types of …
Classification of IDH wild-type glioblastoma tumorspheres into low-and high-invasion groups based on their transcriptional program
Background Glioblastoma (GBM), one of the most lethal tumors, exhibits a highly infiltrative
phenotype. Here, we identified transcription factors (TFs) that collectively modulate invasion …
phenotype. Here, we identified transcription factors (TFs) that collectively modulate invasion …
Effect of combined anti-PD-1 and temozolomide therapy in glioblastoma
ABSTRACT Background: Although programmed death-1 (PD-1) blockade is effective in
treating several types of cancer, the efficacy of this agent in glioblastoma (GBM) is largely …
treating several types of cancer, the efficacy of this agent in glioblastoma (GBM) is largely …
Association between survival and levetiracetam use in glioblastoma patients treated with temozolomide chemoradiotherapy
This study was conducted to assess whether levetiracetam (LEV) affects the survival of
patients with glioblastoma (GBM) treated with concurrent temozolomide (TMZ) …
patients with glioblastoma (GBM) treated with concurrent temozolomide (TMZ) …
Tumor treating fields and maintenance temozolomide for newly-diagnosed glioblastoma: a cost-effectiveness study
GF Guzauskas, EL Pollom, VW Stieber… - Journal of medical …, 2019 - Taylor & Francis
Purpose: The EF-14 trial demonstrated that adding tumor treating fields (TTFields) to
maintenance temozolomide (TMZ) significantly extends progression-free survival (PFS) and …
maintenance temozolomide (TMZ) significantly extends progression-free survival (PFS) and …