Abstract Treatment of muscle invasive urothelial bladder carcinoma (BCa) remains a major
challenge. Comprehensive genomic profiling of tumors and identification of driver mutations …

Post-translational modifications of proteins ensure optimized cellular processes, including
proteostasis, regulated signaling, cell survival, and stress adaptation to maintain a balanced …

Bladder cancer (or urothelial cell carcinoma [UCC]) is characterized by field disease
(malignant alterations in surrounding mucosa) and frequent recurrences. Whole-genome …

Background One third of patients with stage T1 urothelial carcinoma (UC) progress to
muscle-invasive disease requiring radical surgery. Thus, reliable tools are needed for risk …

Background Progression of non–muscle-invasive bladder cancer (NMIBC) to muscle-
invasive bladder cancer (MIBC) is life-threatening and cannot be accurately predicted using …

Background Bladder cancer is a malignant tumor in the urinary system with high mortality
and recurrence rates. However, the causes and recurrence mechanism of bladder cancer …

Abstract During the 2019 International Society of Urological Pathology Consultation
Conference on Molecular Pathology of Urogenital Cancer, the Working Group on Bladder …

The CCND1 gene encodes the protein CyclinD1, which is an important promoter of the cell
cycle and a prognostic and predictive factor in different cancers. CCND1 is amplified to a …

Molecular subtyping has been a major focus of bladder cancer research over the past
decade. Despite many promising associations with clinical outcomes and treatment …

Abstract Background miRNA-424-5p (miR-424-5p) has been implicated in the development
and progression of various tumors. However, the functional mechanisms of miR-424-5p in …