Steps towards standardized quantification of adult neurogenesis

X Zhao, H van Praag - Nature communications, 2020 - nature.com
New neurons are generated in adult mammals. Adult hippocampal neurogenesis is
considered to play an important role in cognition and mental health. The number and …

LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs

JY Kang, Z Wen, D Pan, Y Zhang, Q Li, A Zhong, X Yu… - Science, 2022 - science.org
Postmeiotic spermatids use a unique strategy to coordinate gene expression with
morphological transformation, in which transcription and translation take place at separate …

Inhibition of glycogen synthase kinase 3 by lithium, a mechanism in search of specificity

D Chatterjee, JM Beaulieu - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
Inhibition of Glycogen synthase kinase 3 (GSK3) is a popular explanation for the effects of
lithium ions on mood regulation in bipolar disorder and other mental illnesses, including …

Widespread RNA editing dysregulation in brains from autistic individuals

SS Tran, HI Jun, JH Bahn, A Azghadi… - Nature …, 2019 - nature.com
Transcriptomic analyses of postmortem brains have begun to elucidate molecular
abnormalities in autism spectrum disorder (ASD). However, a crucial pathway involved in …

The multifaceted role of Fragile X-Related Protein 1 (FXR1) in cellular processes: an updated review on cancer and clinical applications

FA Khan, N Fang, W Zhang, S Ji - Cell Death & Disease, 2024 - nature.com
RNA-binding proteins (RBPs) modulate the expression level of several target RNAs (such as
mRNAs) post-transcriptionally through interactions with unique binding sites in the 3 …

RNA-binding protein signaling in adult neurogenesis

JNM Chan, DI Sánchez-Vidaña… - Frontiers in Cell and …, 2022 - frontiersin.org
The process of neurogenesis in the brain, including cell proliferation, differentiation, survival,
and maturation, results in the formation of new functional neurons. During embryonic …

FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors

M Shen, Y Guo, Q Dong, Y Gao, ME Stockton, M Li… - Molecular …, 2021 - nature.com
Parvalbumin interneurons (PVIs) are affected in many psychiatric disorders including
schizophrenia (SCZ), however the mechanism remains unclear. FXR1, a high confident risk …

FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells

JA Smith, EG Curry, RE Blue, C Roden… - Journal of Cell …, 2020 - rupress.org
Fragile-X mental retardation autosomal homologue-1 (FXR1) is a muscle-enriched RNA-
binding protein. FXR1 depletion is perinatally lethal in mice, Xenopus, and zebrafish; …

Acute oligodendrocyte loss with persistent white matter injury in a third trimester equivalent mouse model of fetal alcohol spectrum disorder

J Newville, CF Valenzuela, L Li, LL Jantzie… - Glia, 2017 - Wiley Online Library
Alcohol exposure during central nervous system (CNS) development can lead to fetal
alcohol spectrum disorder (FASD). Human imaging studies have revealed significant white …

Cell signaling in neuronal stem cells

E Navarro Quiroz, R Navarro Quiroz, M Ahmad… - Cells, 2018 - mdpi.com
The defining characteristic of neural stem cells (NSCs) is their ability to multiply through
symmetric divisions and proliferation, and differentiation by asymmetric divisions, thus giving …