[HTML][HTML] Alpha Synuclein Toxicity and Non-Motor Parkinson's

GM Mazzotta, C Conte - Cells, 2024 - mdpi.com
Parkinson's disease (PD) is a common multisystem neurodegenerative disorder affecting
1% of the population over the age of 60 years. The main neuropathological features of PD …

Insights Into Retinal Pathologies in Neurological Disorders: A Focus on Parkinson's Disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, and Alzheimer's …

E Akyuz, FS Aslan, A Hekimoglu… - Journal of …, 2025 - Wiley Online Library
Neurological diseases are central nervous system (CNS) disorders affecting the whole body.
Early diagnosis of the diseases is difficult due to the lack of disease‐specific tests. Adding …

α-Synuclein propagation leads to synaptic abnormalities in the cortex through microglial synapse phagocytosis

D Pérez-Acuña, SJ Shin, KH Rhee, SJ Kim, SJ Lee - Molecular brain, 2023 - Springer
The major neuropathologic feature of Parkinson's disease is the presence of widespread
intracellular inclusions of α-synuclein known as Lewy bodies. Evidence suggests that these …

A topographical atlas of α-synuclein dosage and cell type-specific expression in adult mouse brain and peripheral organs

HM Geertsma, ZA Fisk, L Sauline, A Prigent… - npj Parkinson's …, 2024 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide and presents pathologically with Lewy pathology and dopaminergic …

A new perspective on positive symptoms: expression of damage or self-defence mechanism of the brain?

A Antonioni, EM Raho, M Sensi, F Di Lorenzo… - Neurological …, 2024 - Springer
Usually, positive neurological symptoms are considered as the consequence of a mere,
afinalistic and abnormal increase in function of specific brain areas. However, according to …

Retinal Alterations Predict Early Prodromal Signs of Neurodegenerative Disease

F Casciano, E Zauli, C Celeghini, L Caruso… - International Journal of …, 2024 - mdpi.com
Neurodegenerative diseases are an increasingly common group of diseases that occur late
in life with a significant impact on personal, family, and economic life. Among these …

[HTML][HTML] Retinal ganglion cell type-specific expression of synuclein family members revealed by scRNA-sequencing

Q Yang, L Liu, F He, W Zhao, Z Chen… - … Journal of Medical …, 2024 - ncbi.nlm.nih.gov
Abstract Synuclein family members (Snca, Sncb, and Scng) are expressed in the retina, but
their precise locations and roles are poorly understood. We performed an extensive analysis …

Correction: Retina-to-brain spreading of α-synuclein after intravitreal injection of preformed fibrils

D Pérez-Acuña, KH Rhee, SJ Shin, J Ahn… - Acta Neuropathologica …, 2024 - Springer
Following publication of the original article [1], the authors have identified that an error was
present in two of the images. Figure 1 D and Figure 5 E have incorrect representative …

A topographical atlas of αSyn dosage and cell-type expression in the mouse brain and periphery

HM Geertsma, ZA Fisk, L Sauline, A Prigent, K Kurgat… - bioRxiv, 2023 - biorxiv.org
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide and presents pathologically with Lewy pathology and dopaminergic neuron loss …

A topographical atlas of α-synuclein cell type-specific expression in adult mouse brain and peripheral organs

MWC Rousseaux, H Geertsma, Z Fisk, L Sauline… - 2023 - researchsquare.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide and presents pathologically with Lewy pathology and dopaminergic neuron loss …