The academic literature on and industrial practice of control of solution crystallization
processes have seen major advances in the past 15 years that have been enabled by …

Papers and patents that deal with polymorphism (crystal systems for which a substance can
exist in structures defined by different unit cells and where each of the forms has the same …

Now it is time to move from the general principles to the practice. The efforts made by the
analytical chemistry and chemistry community opinion during the 2011 International Year of …

Crystallization is one of the important unit operations for the separation and purification of
solid products in the chemical, pharmaceutical, and pesticide industries, especially for …

The purpose of this paper is to provide a summary of the current state of the application of
process systems engineering tools in the pharmaceutical industry. In this paper, we present …

Using energetic materials (EMs) products with impure solid forms in practical application
scenarios will lead to a series of serious consequences in terms of safety, mechanics …

Raman spectroscopy, particle vision and measurement (PVM), and infrared spectroscopy
have already been used singularly to detect nucleation and polymorphic transformations …

Supersaturation is the key driving force in crystallization operations, determining nucleation
and growth kinetics, and heavily influencing physical mechanisms such as agglomeration …

Pharmaceutical regulatory bodies require minimal presence of solvent in an active
pharmaceutical ingredient (API) after crystallization. From a processing point of view bigger …

During the manufacturing of active pharmaceutical ingredients crystalline products in the
purest forms are required. Quite often multiple components are present during …