Stem cells (SCs) maintain tissue homeostasis and repair wounds. Despite marked variation
in tissue architecture and regenerative demands, SCs often follow similar paradigms in …

Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …

Tissue repair is critical for animal survival. The skin epidermis is particularly exposed to
injuries, which necessitates rapid repair. The coordinated action of distinct epidermal stem …

Tissues have a natural capacity to replace dying cells and to heal wounds. This ability
resides in resident stem cells, which self-renew, preserve, and repair their tissue during …

The skin is the largest organ of the body, which meets the environment most directly. Thus,
the skin is vulnerable to various damages, particularly burn injury. Skin wound healing is a …

Fibroblasts are the major mesenchymal cell type in connective tissue and deposit the
collagen and elastic fibres of the extracellular matrix (ECM). Even within a single tissue …

The murine epidermis with its hair follicles represents an invaluable model system for tissue
regeneration and stem cell research. Here we used single-cell RNA-sequencing to reveal …

Background At the surface of body organs, epithelial tissues must withstand harsh external
environments. To do so, they rely heavily upon stem cells to replenish and repair wounds …

The tarsal glands of Meibom (glandulae tarsales) are large sebaceous glands located in the
eyelids and, unlike those of the skin, are unassociated with hairs. According to Duke-Elder …

Significance: Scarring of the skin from burns, surgery, and injury constitutes a major burden
on the healthcare system. Patients affected by major scars, particularly children, suffer from …