Aspirin and colorectal cancer: the promise of precision chemoprevention

DA Drew, Y Cao, AT Chan - Nature Reviews Cancer, 2016 - nature.com
Aspirin (acetylsalicylic acid) has become one of the most commonly used drugs, given its
role as an analgesic, antipyretic and agent for cardiovascular prophylaxis. Several decades …

Chemoprevention of colorectal cancer

BW Katona, JM Weiss - Gastroenterology, 2020 - Elsevier
Although colorectal cancer (CRC) screening has reduced the incidence of and mortality from
CRC, chemoprevention strategies have the potential to further reduce CRC incidence and …

Lifestyle risk factors for serrated colorectal polyps: a systematic review and meta-analysis

L Bailie, MB Loughrey, HG Coleman - Gastroenterology, 2017 - Elsevier
Background & Aims Certain subsets of colorectal serrated polyps (SP) have malignant
potential. We performed a systematic review and meta-analysis to investigate the …

Aspirin in the prevention of colorectal neoplasia

DA Drew, AT Chan - Annual review of medicine, 2021 - annualreviews.org
High-quality evidence indicates that regular use of aspirin is effective in reducing the risk for
precancerous colorectal neoplasia and colorectal cancer (CRC). This has led to US and …

Aspirin use and incidence of colorectal cancer according to lifestyle risk

DR Sikavi, K Wang, W Ma, DA Drew, S Ogino… - JAMA …, 2024 - jamanetwork.com
Importance Aspirin reduces the risk of colorectal cancer (CRC). Identifying individuals more
likely to benefit from regular aspirin use for CRC prevention is a high priority. Objective To …

Colorectal cancer chemoprevention: a dream coming true?

M Lepore Signorile, V Grossi, C Fasano… - International Journal of …, 2023 - mdpi.com
Colorectal cancer (CRC) is one of the deadliest forms of cancer worldwide. CRC
development occurs mainly through the adenoma-carcinoma sequence, which can last …

Baseline C-reactive protein level predicts survival of early-stage lung cancer: evidence from a systematic review and meta-analysis

G Leuzzi, C Galeone, M Gisabella, L Duranti… - Tumori …, 2016 - journals.sagepub.com
Purpose The prognostic impact of baseline C-reactive protein (CRP) in non-small-cell lung
cancer (NSCLC) is debated. To evaluate this issue, we performed a systematic review and …

Effects of NSAIDs on the risk factors of colorectal cancer: a mini review

T Hamoya, G Fujii, S Miyamoto, M Takahashi… - Genes and …, 2016 - Springer
Evidence from epidemiological and experimental studies has shown that non-steroidal anti-
inflammatory drugs (NSAIDs) reduce the risk of colorectal cancer (CRC). The function of …

Influence of smoking, body mass index, and other factors on the preventive effect of nonsteroidal anti-inflammatory drugs on colorectal cancer risk

X Wang, AT Chan, ML Slattery, J Chang-Claude… - Cancer research, 2018 - AACR
Nonsteroidal anti-inflammatory drugs'(NSAID) use has consistently been associated with
lower risk of colorectal cancer; however, studies showed inconsistent results on which …

NSAID use and somatic exomic mutations in Barrett's esophagus

PC Galipeau, KM Oman, TG Paulson, CA Sanchez… - Genome Medicine, 2018 - Springer
Background Use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has
been shown to protect against tetraploidy, aneuploidy, and chromosomal alterations in the …