The RIP homotypic interaction motif (RHIM) is a conserved protein domain that is
approximately 18–22 amino acids in length. In humans, four proteins carrying RHIM …

Cytomegalovirus (CMV) has successfully established a long-lasting latent infection in
humans due to its ability to counteract the host antiviral innate immune response. During …

Viruses are obligate intracellular pathogens as their replication depends on the metabolism
of the host cell. The induction of cellular suicide, known as programmed cell death (PCD) …

Cytomegalovirus (CMV) is a widely prevalent herpesvirus that reaches seroprevalence rates
of up to 95% in several parts of the world. The majority of CMV infections are asymptomatic …

CD8 T cells are the predominant effector cells of adaptive immunity in preventing
cytomegalovirus (CMV) multiple-organ disease caused by cytopathogenic tissue infection …

Host control over infectious disease relies on the ability of cells in multicellular organisms to
detect and defend against pathogens to prevent disease. Evolution affords mammals with a …

Cytomegaloviruses, species-specific members of the betaherpesviruses, encode an
impressive array of immune evasion strategies committed to the manipulation of the host …

Murine cytomegalovirus protein M45 contains a RIP homotypic interaction motif (RHIM) that
is sufficient to confer protection of infected cells against necroptotic cell death …

Despite the usefulness of guinea pig cytomegalovirus (GPCMV) for studies on congenital
CMV infection, its viral mechanisms for the evasion of host defense strategies have not been …

(1) Background: Infection with human cytomegalovirus (HCMV) leads to the production and
release of subviral particles, termed Dense Bodies (DB). They are enclosed by a membrane …