The~ 100 MB genome of C. elegans codes for~ 20,000 protein-coding genes many of which
are required for the function of the nervous system, composed of 302 neurons in the adult …

Synaptic plasticity is a fundamental property of neurons referring to the activity-dependent
changes in the strength and efficacy of synaptic transmission at preexisting synapses. Such …

Homozygous SMN1 loss causes spinal muscular atrophy (SMA), the most common lethal
genetic childhood motor neuron disease. SMN1 encodes SMN, a ubiquitous housekeeping …

Various metals have been associated with the pathogenesis of Alzheimer's disease (AD),
principally heavy metals that are environmental pollutants (such as As, Cd, Hg, and Pb) and …

Calcium signaling in neurons as in other cell types can lead to varied changes in cellular
function. Neuronal Ca2+ signaling processes have also become adapted to modulate the …

Calcium signaling, in addition to its numerous physiological roles, is also implicated in
several pathological conditions including cancer. An increasing body of evidence suggest …

Neuronal signal transmission depends on the frequency, pattern, and timing of spike output,
each of which are shaped by spike afterhyperpolarizations (AHPs). There are classically …

The central nervous system (CNS) regulates and coordinates an extensive array of complex
processes requiring harmonious regulation of specific genes. CNS disorders represent a …

V-ATPases are rotary proton pumps that serve as signaling hubs with numerous protein
binding partners. CryoEM with exhaustive focused classification allowed detection of …

Alzheimer's disease (AD) presents a significant challenge to global health. It is characterized
by progressive cognitive deterioration and increased rates of morbidity and mortality among …