Signaling by the integrated stress response kinase PKR is fine-tuned by dynamic clustering

F Zappa, NL Muniozguren, MZ Wilson… - Journal of Cell …, 2022 - rupress.org
The double-stranded RNA sensor kinase PKR is one of four integrated stress response
(ISR) sensor kinases that phosphorylate the α subunit of eukaryotic initiation factor 2 (eIF2α) …

Targeting mitochondrial metabolites and nucleic acids as an anti-inflammatory strategy

Y Min, LAJ O'Neill - Frontiers in Drug Discovery, 2023 - frontiersin.org
Mitochondrial metabolites and their derivatives have been the focus of recent efforts to
develop new anti-inflammatory therapeutics. The widely used therapeutic agents dimethyl …

Mitochondrial double-stranded RNAs as a pivotal mediator in the pathogenesis of Sjӧgren's syndrome

J Yoon, M Lee, AA Ali, YR Oh, YS Choi, S Kim… - … Therapy-Nucleic Acids, 2022 - cell.com
Sjӧgren's syndrome (SS) is a systemic autoimmune disease that targets the exocrine
glands, resulting in impaired saliva and tear secretion. To date, type I interferons (I-IFNs) are …

Microglial innate and adaptive immune function modulates disease pathology in and environmental pesticide model of Parkinson's disease

SM Rocha - 2022 - search.proquest.com
Parkinson's Disease (PD) is the world's foremost movement disorder with pathological
features including loss of dopaminergic neurons (DAn) within the substantia nigra pars …

Inhibition of mitochondrial fission and protein kinase R improves progesterone in placental stress

UK Kolac - Journal of Molecular Endocrinology, 2023 - jme.bioscientifica.com
Placenta synthesizes hormones that play a vital role in adapting maternal physiology and
supporting fetal growth. This study aimed to explore the link between progesterone, a key …