Multiple sclerosis disease-modifying therapy and the COVID-19 pandemic: implications on the risk of infection and future vaccination

C Zheng, I Kar, CK Chen, C Sau, S Woodson, A Serra… - CNS drugs, 2020 - Springer
Abstract The coronavirus 2019 (COVID-19) pandemic is expected to linger. Decisions
regarding initiation or continuation of disease-modifying therapy for multiple sclerosis have …

UK consensus on pregnancy in multiple sclerosis:'Association of British Neurologists' guidelines

R Dobson, P Dassan, M Roberts, G Giovannoni… - Practical …, 2019 - pn.bmj.com
Multiple sclerosis (MS) is more common in women than men and is most commonly
diagnosed in early adulthood; thus, many patients will not have completed their families at …

Comparison of switching to 6-week dosing of natalizumab versus continuing with 4-week dosing in patients with relapsing-remitting multiple sclerosis (NOVA): a …

JF Foley, G Defer, LZ Ryerson, JA Cohen… - The Lancet …, 2022 - thelancet.com
Background Treatment with natalizumab once every 4 weeks is approved for patients with
relapsing-remitting multiple sclerosis, but is associated with a risk of progressive multifocal …

Risk of natalizumab-associated PML in patients with MS is reduced with extended interval dosing

LZ Ryerson, J Foley, IH Chang, I Kister, G Cutter… - Neurology, 2019 - AAN Enterprises
Objective To use the large dataset from the Tysabri Outreach: Unified Commitment to Health
(TOUCH) program to compare progressive multifocal leukoencephalopathy (PML) risk with …

Ocrelizumab extended interval dosing in multiple sclerosis in times of COVID-19

L Rolfes, M Pawlitzki, S Pfeuffer, C Nelke… - Neurology …, 2021 - AAN Enterprises
Objective To evaluate the clinical consequences of extended interval dosing (EID) of
ocrelizumab in relapsing-remitting multiple sclerosis (RRMS) during the coronavirus disease …

Pathogenesis of progressive multifocal leukoencephalopathy and risks associated with treatments for multiple sclerosis: a decade of lessons learned

EO Major, TA Yousry, DB Clifford - The Lancet Neurology, 2018 - thelancet.com
Progressive multifocal leukoencephalopathy (PML) is a rare, devastating demyelinating
disease of the CNS caused by the JC virus (JCV) that occurs in patients with compromised …

Natalizumab in multiple sclerosis treatment: from biological effects to immune monitoring

K Khoy, D Mariotte, G Defer, G Petit… - Frontiers in …, 2020 - frontiersin.org
Multiple sclerosis is a chronic demyelinating disease of the central nervous system (CNS)
with an autoimmune component. Among the recent disease-modifying treatments available …

Treatment optimization in multiple sclerosis: Canadian MS working group recommendations

MS Freedman, V Devonshire, P Duquette… - Canadian Journal of …, 2020 - cambridge.org
The Canadian Multiple Sclerosis Working Group has updated its treatment optimization
recommendations (TORs) on the optimal use of disease-modifying therapies for patients …

The ocrelizumab phase II extension trial suggests the potential to improve the risk: Benefit balance in multiple sclerosis.

D Baker, G Pryce, LK James, M Marta… - Multiple sclerosis and …, 2020 - Elsevier
Objective Ocrelizumab inhibits relapsing multiple sclerosis when administered every six
months. Based on potential similar memory B cell depletion mechanisms with cladribine and …

Consensus recommendations for the diagnosis and treatment of multiple sclerosis: 2019 revisions to the MENACTRIMS guidelines

B Yamout, M Sahraian, S Bohlega, M Al-Jumah… - Multiple sclerosis and …, 2020 - Elsevier
With evolving diagnostic criteria and the advent of new oral and parenteral therapies for MS,
most current diagnostic and treatment algorithms need revision and updating. The diagnosis …