Narcolepsy—clinical spectrum, aetiopathophysiology, diagnosis and treatment

CLA Bassetti, A Adamantidis, D Burdakov… - Nature Reviews …, 2019 - nature.com
Narcolepsy is a rare brain disorder that reflects a selective loss or dysfunction of orexin (also
known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is …

The neurobiological basis of narcolepsy

CE Mahoney, A Cogswell, IJ Koralnik… - Nature Reviews …, 2019 - nature.com
Narcolepsy is the most common neurological cause of chronic sleepiness. The discovery
about 20 years ago that narcolepsy is caused by selective loss of the neurons producing …

Neural network analysis of sleep stages enables efficient diagnosis of narcolepsy

JB Stephansen, AN Olesen, M Olsen, A Ambati… - Nature …, 2018 - nature.com
Abstract Analysis of sleep for the diagnosis of sleep disorders such as Type-1 Narcolepsy
(T1N) currently requires visual inspection of polysomnography records by trained scoring …

Narcolepsy

BR Kornum, S Knudsen, HM Ollila, F Pizza… - Nature reviews Disease …, 2017 - nature.com
Narcolepsy is a chronic sleep disorder that has a typical onset in adolescence and is
characterized by excessive daytime sleepiness, which can have severe consequences for …

Continuing challenges in influenza

RG Webster, EA Govorkova - Annals of the New York Academy …, 2014 - Wiley Online Library
Influenza is an acute respiratory disease in mammals and domestic poultry that emerges
from zoonotic reservoirs in aquatic birds and bats. Although influenza viruses are among the …

[HTML][HTML] Diagnosis of central disorders of hypersomnolence: a reappraisal by European experts

GJ Lammers, CLA Bassetti, L Dolenc-Groselj… - Sleep medicine …, 2020 - Elsevier
The aim of this European initiative is to facilitate a structured discussion to improve the next
edition of the International Classification of Sleep Disorders (ICSD), particularly the chapter …

Incidence of narcolepsy after H1N1 influenza and vaccinations: systematic review and meta-analysis

TO Sarkanen, APE Alakuijala, YA Dauvilliers… - Sleep medicine …, 2018 - Elsevier
An increased incidence of narcolepsy was seen in many countries after the pandemic H1N1
influenza vaccination campaign in 2009–2010. The H1N1 vaccine–narcolepsy connection is …

Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination

M Partinen, BR Kornum, G Plazzi, P Jennum… - The Lancet …, 2014 - thelancet.com
Narcolepsy is a sleep disorder characterised by loss of hypothalamic hypocretin (orexin)
neurons. The prevalence of narcolepsy is about 30 per 100 000 people, and typical age at …

Delayed diagnosis of narcolepsy: characterization and impact

MJ Thorpy, AC Krieger - Sleep medicine, 2014 - Elsevier
Narcolepsy, a chronic neurologic condition resulting from dysregulation of the sleep–wake
cycle, usually has an onset at an early age. However, a long delay until diagnosis has been …

Narcolepsy

L Barateau, F Pizza, G Plazzi… - Journal of Sleep …, 2022 - Wiley Online Library
This article addresses the clinical presentation, diagnosis, pathophysiology and
management of narcolepsy type 1 and 2, with a focus on recent findings. A low level of …