The Physiology of Protein S-acylation
LH Chamberlain, MJ Shipston - Physiological reviews, 2015 - journals.physiology.org
Protein S-acylation, the only fully reversible posttranslational lipid modification of proteins, is
emerging as a ubiquitous mechanism to control the properties and function of a diverse …
emerging as a ubiquitous mechanism to control the properties and function of a diverse …
A not-so-ancient grease history: click chemistry and protein lipid modifications
Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …
Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment
T Kobayashi, PY Lam, H Jiang… - Blood, The Journal …, 2020 - ashpublications.org
Natural killer (NK) cells play critical roles in protection against hematological malignancies
but can acquire a dysfunctional state, which limits antitumor immunity. However, the …
but can acquire a dysfunctional state, which limits antitumor immunity. However, the …
Labeling live cells by copper-catalyzed alkyne− azide click chemistry
The copper-catalyzed azide− alkyne cycloaddition (CuAAC) reaction, optimized for
biological molecules in aqueous buffers, has been shown to rapidly label mammalian cells …
biological molecules in aqueous buffers, has been shown to rapidly label mammalian cells …
[HTML][HTML] The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma
V Justilien, MP Walsh, SA Ali, EA Thompson… - Cancer cell, 2014 - cell.com
We report that two oncogenes coamplified on chromosome 3q26, PRKCI and SOX2,
cooperate to drive a stem-like phenotype in lung squamous cell carcinoma (LSCC). Protein …
cooperate to drive a stem-like phenotype in lung squamous cell carcinoma (LSCC). Protein …
The intracellular dynamic of protein palmitoylation
S-palmitoylation describes the reversible attachment of fatty acids (predominantly palmitate)
onto cysteine residues via a labile thioester bond. This posttranslational modification …
onto cysteine residues via a labile thioester bond. This posttranslational modification …
Site-specific analysis of protein S-acylation by resin-assisted capture [S]
Protein S-acylation is a major posttranslational modification whereby a cysteine thiol is
converted to a thioester. A prototype is S-palmitoylation (fatty acylation), in which a protein …
converted to a thioester. A prototype is S-palmitoylation (fatty acylation), in which a protein …
[HTML][HTML] Fatty acid mobilization from adipose tissue is mediated by CD36 posttranslational modifications and intracellular trafficking
AC Daquinag, Z Gao, C Fussell, L Immaraj… - JCI insight, 2021 - ncbi.nlm.nih.gov
The mechanism controlling long-chain fatty acid (LCFA) mobilization from adipose tissue is
not well understood. Here, we investigated how the LCFA transporter CD36 regulates this …
not well understood. Here, we investigated how the LCFA transporter CD36 regulates this …
Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach
Malaria is an infectious disease caused by parasites of the genus Plasmodium, which leads
to approximately one million deaths per annum worldwide. Chemical validation of new …
to approximately one million deaths per annum worldwide. Chemical validation of new …
Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation
YC Kim, SE Lee, SK Kim, HD Jang, I Hwang… - Nature chemical …, 2019 - nature.com
Abstract Toll-like receptor (TLR)/myeloid differentiation primary response protein (MYD88)
signaling aggravates sepsis by impairing neutrophil migration to infection sites. However …
signaling aggravates sepsis by impairing neutrophil migration to infection sites. However …