pH-responsive polymeric nanomaterials for the treatment of oral biofilm infections

GJ Jeong, MA Rather, F Khan, N Tabassum… - Colloids and Surfaces B …, 2023 - Elsevier
Bacterial and fungal pathogens forming oral biofilms present significant public health
challenges due to the failure of antimicrobial drugs. The ability of biofilms to lower pH levels …

Glycosylation and lipidation strategies: Approaches for improving antimicrobial peptide efficacy

R Bellavita, S Braccia, S Galdiero, A Falanga - Pharmaceuticals, 2023 - mdpi.com
Antimicrobial peptides (AMPs) have recently gained attention as a viable solution for
combatting antibiotic resistance due to their numerous advantages, including their broad …

[HTML][HTML] Plastic pollution and fungal, protozoan, and helminth pathogens–A neglected environmental and public health issue?

MJ Ormsby, A Akinbobola, RS Quilliam - Science of the Total Environment, 2023 - Elsevier
Plastic waste is ubiquitous in the environment and can become colonised by distinct
microbial biofilm communities, known collectively as the 'plastisphere.'The plastisphere can …

Effect of Myrtenol and Its Synergistic Interactions with Antimicrobial Drugs in the Inhibition of Single and Mixed Biofilms of Candida auris and Klebsiella pneumoniae

A Maione, A La Pietra, E de Alteriis, A Mileo… - Microorganisms, 2022 - mdpi.com
The increased incidence of mixed infections requires that the scientific community develop
novel antimicrobial molecules. Essential oils and their bioactive pure compounds have been …

Unveiling the mechanism of action of acylated temporin L analogues against multidrug-resistant Candida albicans

R Bellavita, A Falanga, F Merlino… - Journal of Enzyme …, 2023 - Taylor & Francis
The increasing resistance of fungi to conventional antifungal drugs has prompted worldwide
the search for new compounds. In this work, we investigated the antifungal properties of …

Mixed fungal biofilms: From mycobiota to devices, a new challenge on clinical practice

PS Costa, A Prado, NP Bagon, M Negri, TIE Svidzinski - Microorganisms, 2022 - mdpi.com
Most current protocols for the diagnosis of fungal infections are based on culture-dependent
methods that allow the evaluation of fungal morphology and the identification of the etiologic …

Synthetic Amphipathic β-Sheet Temporin-Derived Peptide with Dual Antibacterial and Anti-Inflammatory Activities

R Bellavita, E Buommino, B Casciaro, F Merlino… - Antibiotics, 2022 - mdpi.com
Temporin family is one of the largest among antimicrobial peptides (AMPs), which act mainly
by penetrating and disrupting the bacterial membranes. To further understand the …

Myxinidin-derived peptide against biofilms caused by cystic fibrosis emerging pathogens

R Bellavita, A Maione, S Braccia, M Sinoca… - International Journal of …, 2023 - mdpi.com
Chronic lung infections in cystic fibrosis (CF) patients are triggered by multidrug-resistant
bacteria such as Pseudomonas aeruginosa, Achromobacter xylosoxidans, and …

Effect of Escin Alone or in Combination with Antifungal Agents on Resistant Candida glabrata Biofilms: Mechanisms of Action

A Maione, M Imparato, M Galdiero, E Alteriis, A Feola… - Antibiotics, 2023 - mdpi.com
Nowadays, the increase in antimicrobial-resistant fungi (AMR) is certainly a major health
concern, and the development of alternative therapeutic strategies has become crucial …

Strategic Single-Residue Substitution in the Antimicrobial Peptide Esc(1–21) Confers Activity against Staphylococcus aureus, Including Drug-Resistant and Biofilm …

MR Loffredo, B Casciaro, R Bellavita… - ACS Infectious …, 2024 - ACS Publications
Staphylococcus aureus, a bacterium resistant to multiple drugs, is a significant cause of
illness and death worldwide. Antimicrobial peptides (AMPs) provide an excellent potential …