As a lipoxygenase (LOX), arachidonate 15-lipoxygenase type B (ALOX15B) peroxidizes
polyenoic fatty acids (PUFAs) including arachidonic acid (AA), eicosapentaenoic acid (EPA) …

Because of their historical mode of action, endocrine-disrupting chemicals (EDCs) are
associated with sex-steroid receptors, namely the two estrogen receptors (ERα and ERβ) …

Simple Summary In this review, we present current knowledge of sex hormones in the
process of development of malignant diseases. The impact of sex hormones on immune …

Simple Summary Although epithelial-to-mesenchymal transition (EMT) is a well-known
cellular process involved during normal embryogenesis and wound healing, it also has a …

The potential risks to human health posed by the overuse of gonadal steroid hormones
(GSH), make it essential to develop a sensitive method for monitoring their levels. Recently …

Prostate cancer (PC) has previously been established as a cold tumor and develops in an
inert immunosuppressive environment. Current research focuses on altering the immune …

The molecular determinants of the heterogenic course of prostate cancer (PC) remain
elusive. We aimed to determine the drivers predisposing to unfavorable PC outcomes …

Simple Summary Estrogens are steroid hormones that interact with nuclear receptors (ERα
and ERβ) and a membrane G-protein-coupled receptor (GPER) to regulate multiple …

Due to its sensitivity to hormonal signaling, the mammary gland is often referred to as a
sentinel organ for the study of endocrine-disrupting chemicals (EDCs), environmental …

Just like the androgen receptor (AR), the estrogen receptor α (ERα) is expressed in the
prostate and is thought to influence prostate cancer (PCa) biology. Yet the incomplete …