Aortic aneurysm is a vascular disease whereby the ECM (extracellular matrix) of a blood
vessel degenerates, leading to dilation and eventually vessel wall rupture. Recently, it was …

Aortic aneurysm is a life-threatening disease due to the risk of aortic rupture. The only
curative treatment available relies on surgical approaches; drug-based therapies are …

The aortic wall is composed of highly dynamic cell populations and extracellular matrix. In
response to changes in the biomechanical environment, aortic cells and extracellular matrix …

The aorta is a blood vessel that provides a low-resistance path for blood flow directed from
the heart to peripheral organs and tissues. However, the aorta has another central …

The embryonic lineage of intramural cells, microstructural organization of the extracellular
matrix, local luminal and wall geometry, and haemodynamic loads vary along the length of …

Smooth muscle cell (SMC) proliferation has been thought to limit the progression of thoracic
aortic aneurysm and dissection (TAAD) because loss of medial cells associates with …

Thoracic aortic aneurysms are life-threatening lesions that afflict young and old individuals
alike. They frequently associate with genetic mutations and are characterized by reduced …

Metabolic reprogramming of vascular smooth muscle cell (VSMC) plays a critical role in the
pathogenesis of thoracic aortic dissection (TAD). Previous researches have mainly focused …

Thoracic aortopathy–aneurysm, dissection, and rupture–is increasingly responsible for
significant morbidity and mortality. Advances in medical genetics and imaging have …

Thoracic aortopathy, especially aneurysm, dissection, and rupture, is responsible for
significant morbidity and mortality. Uncontrolled hypertension and aging are primary risk …