Role of vascular smooth muscle cell phenotypic switching and calcification in aortic aneurysm formation: involvement of vitamin K-dependent processes
P Petsophonsakul, M Furmanik, R Forsythe… - … , and vascular biology, 2019 - Am Heart Assoc
Aortic aneurysm is a vascular disease whereby the ECM (extracellular matrix) of a blood
vessel degenerates, leading to dilation and eventually vessel wall rupture. Recently, it was …
vessel degenerates, leading to dilation and eventually vessel wall rupture. Recently, it was …
Diabetes and aortic aneurysm: current state of the art
Aortic aneurysm is a life-threatening disease due to the risk of aortic rupture. The only
curative treatment available relies on surgical approaches; drug-based therapies are …
curative treatment available relies on surgical approaches; drug-based therapies are …
Aortic aneurysms and dissections series
YH Shen, SA LeMaire, NR Webb… - … , and vascular biology, 2020 - Am Heart Assoc
The aortic wall is composed of highly dynamic cell populations and extracellular matrix. In
response to changes in the biomechanical environment, aortic cells and extracellular matrix …
response to changes in the biomechanical environment, aortic cells and extracellular matrix …
Killing me unsoftly: causes and mechanisms of arterial stiffness
AN Lyle, U Raaz - Arteriosclerosis, thrombosis, and vascular …, 2017 - Am Heart Assoc
The aorta is a blood vessel that provides a low-resistance path for blood flow directed from
the heart to peripheral organs and tissues. However, the aorta has another central …
the heart to peripheral organs and tissues. However, the aorta has another central …
Differential cell-matrix mechanoadaptations and inflammation drive regional propensities to aortic fibrosis, aneurysm or dissection in hypertension
MR Bersi, R Khosravi, AJ Wujciak… - Journal of The …, 2017 - royalsocietypublishing.org
The embryonic lineage of intramural cells, microstructural organization of the extracellular
matrix, local luminal and wall geometry, and haemodynamic loads vary along the length of …
matrix, local luminal and wall geometry, and haemodynamic loads vary along the length of …
[HTML][HTML] Chronic mTOR activation induces a degradative smooth muscle cell phenotype
Smooth muscle cell (SMC) proliferation has been thought to limit the progression of thoracic
aortic aneurysm and dissection (TAAD) because loss of medial cells associates with …
aortic aneurysm and dissection (TAAD) because loss of medial cells associates with …
Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms
Thoracic aortic aneurysms are life-threatening lesions that afflict young and old individuals
alike. They frequently associate with genetic mutations and are characterized by reduced …
alike. They frequently associate with genetic mutations and are characterized by reduced …
Branched-chain amino acid catabolic defect in vascular smooth muscle cells drives thoracic aortic dissection via mTOR hyperactivation
L Yu, T Huang, J Zhao, Z Zhou, Z Cao, Y Chi… - Free Radical Biology …, 2024 - Elsevier
Metabolic reprogramming of vascular smooth muscle cell (VSMC) plays a critical role in the
pathogenesis of thoracic aortic dissection (TAD). Previous researches have mainly focused …
pathogenesis of thoracic aortic dissection (TAD). Previous researches have mainly focused …
[HTML][HTML] Roles of mTOR in thoracic aortopathy understood by complex intracellular signaling interactions
Thoracic aortopathy–aneurysm, dissection, and rupture–is increasingly responsible for
significant morbidity and mortality. Advances in medical genetics and imaging have …
significant morbidity and mortality. Advances in medical genetics and imaging have …
Central artery stiffness and thoracic aortopathy
JD Humphrey, G Tellides - American Journal of Physiology …, 2019 - journals.physiology.org
Thoracic aortopathy, especially aneurysm, dissection, and rupture, is responsible for
significant morbidity and mortality. Uncontrolled hypertension and aging are primary risk …
significant morbidity and mortality. Uncontrolled hypertension and aging are primary risk …