Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …

Cancer researchers have traditionally used the mouse and the rat as staple model
organisms. These animals are very short-lived, reproduce rapidly and are highly prone to …

Mutational processes underlie cancer initiation and progression. Signatures of these
processes in cancer genomes may explain cancer etiology and could hold diagnostic and …

The germline mutation rate has been extensively studied and has been found to vary greatly
between species, but much less is known about the somatic mutation rate in multicellular …

DNA repair has been hypothesized to be a longevity determinant, but the evidence for it is
based largely on accelerated aging phenotypes of DNA repair mutants. Here, using a panel …

Abstract The Free Radical Theory of Ageing, was first proposed by Denham Harman in the
mid-1950's, based largely on work conducted by Rebeca Gerschman and Daniel Gilbert. At …

DNA damage contributes to brain aging and neurodegenerative diseases. However, the
factors stimulating DNA repair to stave off functional decline remain obscure. We show that …

Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …

Zinc-finger nuclease (ZFN)-based in vivo genome editing is a novel treatment that can
potentially provide lifelong protein replacement with single intravenous administration …

Genetic and pharmacological intervention studies have identified evolutionarily conserved
and functionally interconnected networks of cellular energy homeostasis, nutrient-sensing …