The endogenous ligands for the LT, lipoxin (LX) and oxoeicosanoid receptors are bioactive
products produced by the action of the lipoxygenase family of enzymes. The LT receptors …

5-lipoxygenase is an enzyme responsible for the synthesis of a range of bioactive lipids
signalling molecules known collectively as eicosanoids. 5-lipoxygenase metabolites such as …

The seven-transmembrane G protein-coupled receptors activated by leukotrienes are
divided into two subclasses based on their ligand specificity for either leukotriene B4 or the …

Long-standing inflammation has emerged as a hallmark of neoplastic transformation of
epithelial cells and may be a limiting factor of successful conventional tumor therapies. A …

Acute myeloid leukemia (AML) is associated with poor clinical outcome and the
development of more effective therapies is urgently needed. G protein-coupled receptors …

Cancer remains a leading cause of death worldwide, despite many advances being made in
recent decades. Changes in the tumor microenvironment, including dysregulated immunity …

Immunotherapy targeting programmed death-ligand 1 (PD-L1) or PD-1 in solid tumors has
been shown to be clinically beneficial. However, in colorectal cancer (CRC), only a subset of …

Developing novel chemo-prevention techniques and advancing treatment are key elements
to beating lung cancer, the most common cause of cancer mortality worldwide. Our previous …

Previous in vitro and in vivo studies have demonstrated the potential of using cysteinyl
leukotriene receptor antagonists (LTRAs) for chemoprevention, but this has not been …

Colon cancer is a therapy-resistant cancer with a low 5-year survival frequency. The drug 5-
fluorouracil (5-FU) has been used as a first-line therapy in metastatic colon cancer in …