IL-17, a potent proinflammatory cytokine, has been shown to intimately contribute to the
formation, growth, and metastasis of a wide range of malignancies. Recent studies implicate …

Prostate cancer is a major cause of cancer morbidity and mortality. Intra-prostatic
inflammation is a risk factor for prostate carcinogenesis, with diet, chemical injury and an …

Programmed cell death protein 1 (PD-1) acts on PD-1 ligands (PD-L1 and PD-L2) to
suppress activation of cytotoxic T lymphocytes. Interleukin-17 (IL-17) and tumor necrosis …

Many human cancers are dramatically accelerated by chronic inflammation. However, the
specific cellular and molecular elements mediating this effect remain largely unknown …

Lung cancer development is associated with extensive pulmonary inflammation. In addition,
the linkage between chronic obstructive pulmonary disease (COPD) and lung cancer has …

Chronic inflammation has been associated with a variety of human cancers including
prostate cancer. Interleukin-17 (IL-17) is a critical pro-inflammatory cytokine, which has been …

Abstract The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and
recently, all of its related receptors have been discovered. IL-17 was first discovered …

The androgen receptor (AR) is overexpressed and hyperactivated in human castration-
resistant prostate cancer (CRPC). However, the determinants of AR overexpression in …

Background Elucidation of mechanisms regulating bone metastasis has progressed
significantly in recent years and this has translated to many new therapeutic options for …

Th17 cells are a specialized subset of CD4+ T cells that are essential in driving inflammation
during autoimmune disease and infection through a signature cytokine IL-17. Th17 cells …