Foxp3-expressing CD4+ regulatory T (Treg) cells play key roles in the prevention of
autoimmunity and the maintenance of immune homeostasis and represent a major barrier to …

Premature Ovarian Failure and Ovarian Autoimmunity* | Endocrine Reviews | Oxford
Academic Skip to Main Content Advertisement Oxford Academic Journals Books Search …

Neonatal thymectomy (NTx), especially around day 3 after birth, causes various organ-
specific autoimmune diseases in mice. This report shows that:(a) T cells expressing the …

Keratinocyte growth factor (KGF) is a human mitogen that is specific for epithelial cells. The
complementary DNA sequence of KGF demonstrates that it is a member of the fibroblast …

Thymectomy of susceptible strains of mice on day 3 of life results in a spectrum of organ-
specific autoimmunity that can be prevented by reconstitution of the thymectomized animals …

The ability of spermatogenic cells to evade the host immune system and the ability of
systemic inflammation to inhibit male reproductive function represent two of the most …

Abstract Immunoregulatory CD25+ CD4 T cells are thought to arise from the thymus as a
distinct lineage of CD4 T cells specific for self Ags. We used the DO11. 10 TCR transgenic …

It is now well known that natural (17β-estradiol) and synthetic (eg diethylstilbestrol)
estrogens not only affect the reproductive system, but also markedly influence the immune …

Premature ovarian insufficiency (POI) refers to a continuum of decreasing ovarian function in
women before the age of 40. To date, the cause of POI in the majority of cases remain …

We describe a novel experimental system in mice for the study of ovarian autoimmune
disease, a condition encountered in women with premature ovarian failure. The ovarian …