[HTML][HTML] Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies
Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) are being expedited through preclinical and clinical development. Data …
2 (SARS-CoV-2) are being expedited through preclinical and clinical development. Data …
[HTML][HTML] Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
dramatically expedited global vaccine development efforts,–, most targeting the viral …
dramatically expedited global vaccine development efforts,–, most targeting the viral …
[HTML][HTML] Human seasonal influenza under COVID-19 and the potential consequences of influenza lineage elimination
Annual epidemics of seasonal influenza cause hundreds of thousands of deaths, high levels
of morbidity, and substantial economic loss. Yet, global influenza circulation has been …
of morbidity, and substantial economic loss. Yet, global influenza circulation has been …
Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence
GE Hartley, ESJ Edwards, PM Aui, N Varese… - Science …, 2020 - science.org
Lasting immunity following SARS-CoV-2 infection is questioned because serum antibodies
decline in convalescence. However, functional immunity is mediated by long-lived memory T …
decline in convalescence. However, functional immunity is mediated by long-lived memory T …
[HTML][HTML] The quest for a truly universal influenza vaccine
YH Jang, BL Seong - Frontiers in cellular and infection microbiology, 2019 - frontiersin.org
There is an unmet public health need for a universal influenza vaccine (UIV) to provide
broad and durable protection from influenza virus infections. The identification of broadly …
broad and durable protection from influenza virus infections. The identification of broadly …
[HTML][HTML] Development of a pentavalent broadly protective nucleoside-modified mRNA vaccine against influenza B viruses
Messenger RNA (mRNA) vaccines represent a new, effective vaccine platform with high
capacity for rapid development. Generation of a universal influenza virus vaccine with the …
capacity for rapid development. Generation of a universal influenza virus vaccine with the …
Antibodies elicited in humans upon chimeric hemagglutinin-based influenza virus vaccination confer FcγR-dependent protection in vivo
JE Edgar, S Trezise, RM Anthony… - Proceedings of the …, 2023 - National Acad Sciences
Antibody responses against highly conserved epitopes on the stalk domain of influenza
virus hemagglutinin (HA) confer broad protection; however, such responses are limited. To …
virus hemagglutinin (HA) confer broad protection; however, such responses are limited. To …
Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues
Vaccination and infection promote the formation, tissue distribution, and clonal evolution of B
cells, which encode humoral immune memory. We evaluated pediatric and adult blood and …
cells, which encode humoral immune memory. We evaluated pediatric and adult blood and …
[HTML][HTML] Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients
THO Nguyen, M Koutsakos, CE van de Sandt… - Nature …, 2021 - nature.com
How innate and adaptive immune responses work in concert to resolve influenza disease is
yet to be fully investigated in one single study. Here, we utilize longitudinal samples from …
yet to be fully investigated in one single study. Here, we utilize longitudinal samples from …
[HTML][HTML] New technologies for influenza vaccines
Vaccine development has been hampered by the long lead times and the high cost required
to reach the market. The 2020 pandemic, caused by a new coronavirus (SARS-CoV-2) that …
to reach the market. The 2020 pandemic, caused by a new coronavirus (SARS-CoV-2) that …