Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

Metabolic syndrome (MetS) is considered a metabolic disorder that has been steadily
increasing globally and seems to parallel the increasing prevalence of obesity. It consists of …

Glucose is used aerobically and anaerobically to generate energy for cells. Glucose
transporters (GLUTs) are transmembrane proteins that transport glucose across the cell …

Among all the body fluids, breast milk is one of the richest sources of microRNAs (miRNAs).
MiRNAs packaged within the milk exosomes are bioavailable to breastfeeding infants. The …

Obesity is characterized as a complex and multifactorial excess accretion of adipose tissue
(AT) accompanied with alterations in the immune response that affects virtually all age and …

T2DM, as a typical metabolic inflammatory disease, is under the joint regulation of
environmental factors and genetics, combining with a variety of epigenetic changes. Apart …

The prevalence of obesity has reached pandemic levels worldwide, leading to a lower
quality of life and higher health costs. Obesity is a major risk factor for noncommunicable …

Background Different phenotypes of macrophages (M0, M1 and M2 Mφs) have been
demonstrated to play distinct roles in regulating mesenchymal stem cells in various in vitro …

Metabolic dysfunction-associated fatty liver disease (MAFLD) occurs in a low-grade
inflammatory milieu dependent on highly complex networks that span well-beyond the …

Peroxisome proliferator-activated receptor-γ (PPARγ) belongs to the superfamily of nuclear
receptors that control the transcription of multiple genes. Although it is found in many cells …