Amplification is the primary mode of gene-by-sex interaction in complex human traits

C Zhu, MJ Ming, JM Cole, MD Edge, M Kirkpatrick… - Cell Genomics, 2023 - cell.com
Sex differences in complex traits are suspected to be in part due to widespread gene-by-sex
interactions (GxSex), but empirical evidence has been elusive. Here, we infer the mixture of …

[HTML][HTML] Evaluating the role of sexual antagonism in the evolution of sex chromosomes: new data from fish

SH Smith, K Hsiung, A Böhne - Current Opinion in Genetics & Development, 2023 - Elsevier
The recent increase in available molecular and genomic data for diverse taxa helps to shed
new light on long-standing theories. Research into sex chromosome evolution has …

Investigating diadromy in fishes and its loss in an-omics era

ML Delgado, DE Ruzzante - Iscience, 2020 - cell.com
Diadromy, the predictable movements of individuals between marine and freshwater
environments, is biogeographically and phylogenetically widespread across fishes. Thus …

Searching for signatures of sexually antagonistic selection on stickleback sex chromosomes

AJ Dagilis, JM Sardell… - … of the Royal …, 2022 - royalsocietypublishing.org
Intralocus sexually antagonistic selection occurs when an allele is beneficial to one sex but
detrimental to the other. This form of selection is thought to be key to the evolution of sex …

Heterogeneous histories of recombination suppression on stickleback sex chromosomes

JM Sardell, MP Josephson, AC Dalziel… - Molecular biology …, 2021 - academic.oup.com
How consistent are the evolutionary trajectories of sex chromosomes shortly after they form?
Insights into the evolution of recombination, differentiation, and degeneration can be …

The search for sexually antagonistic genes: Practical insights from studies of local adaptation and statistical genomics

F Ruzicka, L Dutoit, P Czuppon, CY Jordan… - Evolution …, 2020 - academic.oup.com
Sexually antagonistic (SA) genetic variation—in which alleles favored in one sex are
disfavored in the other—is predicted to be common and has been documented in several …

The battle of the sexes in humans is highly polygenic

JM Cole, CB Scott, MM Johnson, PR Golightly… - Proceedings of the …, 2024 - pnas.org
Sex-differential selection (SDS), which occurs when the fitness effects of alleles differ
between males and females, can have profound impacts on the maintenance of genetic …

Is the X chromosome a hot spot for sexually antagonistic polymorphisms? Biases in current empirical tests of classical theory

F Ruzicka, T Connallon - Proceedings of the Royal …, 2020 - royalsocietypublishing.org
Females and males carry nearly identical genomes, which can constrain the evolution of
sexual dimorphism and generate conditions that are favourable for maintaining sexually …

Hiding in plain sight: the Y chromosome and its reinvigorated role in evolutionary processes

W van der Bijl, JE Mank - Evolution Letters, 2024 - academic.oup.com
Recent methodological approaches have expanded our understanding of Y chromosome
sequence, revealed unexpected Y diversity, and sparked a growing realization of its …

Polygenic signals of sex differences in selection in humans from the UK Biobank

F Ruzicka, L Holman, T Connallon - PLoS Biology, 2022 - journals.plos.org
Sex differences in the fitness effects of genetic variants can influence the rate of adaptation
and the maintenance of genetic variation. For example,“sexually antagonistic”(SA) variants …