Parkinson's disease (PD) is a common neurodegenerative disease developed due to the
degeneration of dopaminergic neurons in the substantia nigra. There is no single effective …

Theophylline (3-methyxanthine) is a historically prominent drug used to treat respiratory
diseases, alone or in combination with other drugs. The rapid onset of the COVID-19 …

Aims/hypothesis The objective was to investigate if metformin pharmacokinetics is
modulated by time-of-day in humans using empirical and mechanistic pharmacokinetic …

The advancement in the processing speeds of computing machines has facilitated the
development of complex physiologically based pharmacokinetic (PBPK) models. These …

Metformin is the primary drug for type 2 diabetes treatment and a promising candidate for
other disease treatment. It has significant deviations between individuals in therapy …

Endogenous biomarkers for transporter‐mediated drug‐drug interaction (DDI) predictions
represent a promising approach to facilitate and improve conventional DDI investigations in …

This study provides a whole‐body physiologically‐based pharmacokinetic (PBPK) model of
dextromethorphan and its metabolites dextrorphan and dextrorphan O‐glucuronide for …

Women commonly take medication during lactation. Currently, there is little information
about the exposure-related safety of maternal medicines for breastfed infants. The aim was …

Metformin is considered the first-choice drug for type 2 diabetes treatment. Actually,
pleiotropic effects of metformin have been recognized, and there is evidence that this drug …

The objective of this study was to systematically assess literature datasets and quantitatively
analyze metformin PK in plasma and some tissues of nine species. The pharmacokinetic …