Synaptic AMPA receptor composition in development, plasticity and disease
JM Henley, KA Wilkinson - Nature Reviews Neuroscience, 2016 - nature.com
AMPA receptors (AMPARs) are assemblies of four core subunits, GluA1–4, that mediate
most fast excitatory neurotransmission. The component subunits determine the functional …
most fast excitatory neurotransmission. The component subunits determine the functional …
Structural components of synaptic plasticity and memory consolidation
CH Bailey, ER Kandel… - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Consolidation of implicit memory in the invertebrate Aplysia and explicit memory in the
mammalian hippocampus are associated with remodeling and growth of preexisting …
mammalian hippocampus are associated with remodeling and growth of preexisting …
Proteomic analysis of unbounded cellular compartments: synaptic clefts
Cellular compartments that cannot be biochemically isolated are challenging to
characterize. Here we demonstrate the proteomic characterization of the synaptic clefts that …
characterize. Here we demonstrate the proteomic characterization of the synaptic clefts that …
Optical pooled screens in human cells
Genetic screens are critical for the systematic identification of genes underlying cellular
phenotypes. Pooling gene perturbations greatly improves scalability but is not compatible …
phenotypes. Pooling gene perturbations greatly improves scalability but is not compatible …
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein
Soluble amyloid-β oligomers (Aβo) trigger Alzheimer's disease (AD) pathophysiology and
bind with high affinity to cellular prion protein (PrP C). At the postsynaptic density (PSD) …
bind with high affinity to cellular prion protein (PrP C). At the postsynaptic density (PSD) …
Plasticity during stroke recovery: from synapse to behaviour
Reductions in blood flow to the brain of sufficient duration and extent lead to stroke, which
results in damage to neuronal networks and the impairment of sensation, movement or …
results in damage to neuronal networks and the impairment of sensation, movement or …
A genetically encoded tag for correlated light and electron microscopy of intact cells, tissues, and organisms
X Shu, V Lev-Ram, TJ Deerinck, Y Qi, EB Ramko… - PLoS …, 2011 - journals.plos.org
Electron microscopy (EM) achieves the highest spatial resolution in protein localization, but
specific protein EM labeling has lacked generally applicable genetically encoded tags for in …
specific protein EM labeling has lacked generally applicable genetically encoded tags for in …
Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin
The mouse visual system serves as an accessible model to understand mammalian circuit
wiring. Despite rich knowledge in retinal circuits, the long-range connectivity map from …
wiring. Despite rich knowledge in retinal circuits, the long-range connectivity map from …
High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes
J Schwenk, N Harmel, A Brechet, G Zolles, H Berkefeld… - Neuron, 2012 - cell.com
AMPA-type glutamate receptors (AMPARs) are responsible for a variety of processes in the
mammalian brain including fast excitatory neurotransmission, postsynaptic plasticity, or …
mammalian brain including fast excitatory neurotransmission, postsynaptic plasticity, or …
Synaptic contacts enhance cell-to-cell tau pathology propagation
S Calafate, A Buist, K Miskiewicz, V Vijayan, G Daneels… - Cell reports, 2015 - cell.com
Accumulation of insoluble Tau protein aggregates and stereotypical propagation of Tau
pathology through the brain are common hallmarks of tauopathies, including Alzheimer's …
pathology through the brain are common hallmarks of tauopathies, including Alzheimer's …