AMPA receptors (AMPARs) are assemblies of four core subunits, GluA1–4, that mediate
most fast excitatory neurotransmission. The component subunits determine the functional …

Consolidation of implicit memory in the invertebrate Aplysia and explicit memory in the
mammalian hippocampus are associated with remodeling and growth of preexisting …

Cellular compartments that cannot be biochemically isolated are challenging to
characterize. Here we demonstrate the proteomic characterization of the synaptic clefts that …

Genetic screens are critical for the systematic identification of genes underlying cellular
phenotypes. Pooling gene perturbations greatly improves scalability but is not compatible …

Soluble amyloid-β oligomers (Aβo) trigger Alzheimer's disease (AD) pathophysiology and
bind with high affinity to cellular prion protein (PrP C). At the postsynaptic density (PSD) …

Reductions in blood flow to the brain of sufficient duration and extent lead to stroke, which
results in damage to neuronal networks and the impairment of sensation, movement or …

Electron microscopy (EM) achieves the highest spatial resolution in protein localization, but
specific protein EM labeling has lacked generally applicable genetically encoded tags for in …

The mouse visual system serves as an accessible model to understand mammalian circuit
wiring. Despite rich knowledge in retinal circuits, the long-range connectivity map from …

AMPA-type glutamate receptors (AMPARs) are responsible for a variety of processes in the
mammalian brain including fast excitatory neurotransmission, postsynaptic plasticity, or …

Accumulation of insoluble Tau protein aggregates and stereotypical propagation of Tau
pathology through the brain are common hallmarks of tauopathies, including Alzheimer's …