Efforts at COVID-19 vaccine development: challenges and successes

A Haque, AB Pant - Vaccines, 2020 - mdpi.com
The rapid spread of SARS-CoV-2, the new coronavirus (CoV), throughout the globe poses a
daunting public health emergency. Different preventive efforts have been undertaken in …

Adenoviral vector-based vaccine platform for COVID-19: Current status

VP Chavda, R Bezbaruah, D Valu, B Patel, A Kumar… - Vaccines, 2023 - mdpi.com
The coronavirus disease (COVID-19) breakout had an unimaginable worldwide effect in the
21st century, claiming millions of lives and putting a huge burden on the global economy …

Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue

J Niessl, T Sekine, J Lange, V Konya, M Forkel… - Science …, 2021 - science.org
Cross-reactive CD4+ T cells that recognize severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) are more commonly detected in the peripheral blood of unexposed …

Antigen presentation of mRNA-based and virus-vectored SARS-CoV-2 vaccines

GT Rijkers, N Weterings, A Obregon-Henao… - Vaccines, 2021 - mdpi.com
Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes
Coronavirus Disease 2019 (COVID-19), which has reached pandemic proportions. A …

Why does the severity of COVID-19 differ with age?: understanding the mechanisms underlying the age gradient in outcome following SARS-CoV-2 infection

P Zimmermann, N Curtis - The Pediatric Infectious Disease …, 2022 - journals.lww.com
Although there are many hypotheses for the age-related difference in the severity of COVID-
19, differences in innate, adaptive and heterologous immunity, together with differences in …

COVID-19 and seasonal influenza vaccination: cross-protection, co-administration, combination vaccines, and hesitancy

A Domnich, A Orsi, CS Trombetta, G Guarona… - Pharmaceuticals, 2022 - mdpi.com
SARS-CoV-2 and influenza are the main respiratory viruses for which effective vaccines are
currently available. Strategies in which COVID-19 and influenza vaccines are administered …

Differential T-cell reactivity to endemic coronaviruses and SARS-CoV-2 in community and health care workers

R da Silva Antunes, S Pallikkuth… - The Journal of …, 2021 - academic.oup.com
Herein we measured CD4+ T-cell responses against common cold coronaviruses (CCC)
and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in high-risk health care …

An update review of globally reported SARS-CoV-2 vaccines in preclinical and clinical stages

H Motamedi, MM Ari, S Dashtbin, M Fathollahi… - International …, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the rapidly spreading pandemic COVID-19 in the world. As an effective therapeutic strategy …

[HTML][HTML] COVID-19 disease and autoimmune disorders: A mutual pathway

M Al-Beltagi, NK Saeed, AS Bediwy - World Journal of …, 2022 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19) is a real challenge for humanity with high
morbidity and mortality. Despite being primarily a respiratory illness, COVID-19 can affect …

Mucosal immunity to severe acute respiratory syndrome coronavirus 2 infection

J Fröberg, DA Diavatopoulos - Current opinion in infectious …, 2021 - journals.lww.com
Although most clinical studies focus on antibodies and cellular immunity in peripheral blood,
mucosal immune responses in the respiratory tract play a key role in the early restriction of …