Nonribosomal peptide synthesis—principles and prospects
RD Süssmuth, A Mainz - Angewandte Chemie International …, 2017 - Wiley Online Library
Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …
assemble numerous peptides with large structural and functional diversity. These peptides …
Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology
GH Hur, CR Vickery, MD Burkart - Natural product reports, 2012 - pubs.rsc.org
Covering up to the end of 2011 Many pharmaceuticals on the market today belong to a large
class of natural products called nonribosomal peptides (NRPs). Originating from bacteria …
class of natural products called nonribosomal peptides (NRPs). Originating from bacteria …
The third pillar of bacterial signal transduction: classification of the extracytoplasmic function (ECF) σ factor protein family
The ability of a bacterial cell to monitor and adaptively respond to its environment is crucial
for survival. After one‐and two‐component systems, extracytoplasmic function (ECF) σ …
for survival. After one‐and two‐component systems, extracytoplasmic function (ECF) σ …
[HTML][HTML] The biosynthesis of pyoverdines
MT Ringel, T Brüser - Microbial cell, 2018 - ncbi.nlm.nih.gov
Pyoverdines are fluorescent siderophores of pseudomonads that play important roles for
growth under iron-limiting conditions. The production of pyoverdines by fluorescent …
growth under iron-limiting conditions. The production of pyoverdines by fluorescent …
Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases
Covering: up to fall 2022. Nonribosomal peptide synthetases (NRPSs) are a family of
modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural …
modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural …
An overview of siderophore biosynthesis among fluorescent Pseudomonads and new insights into their complex cellular organization
Siderophores are iron‐chelating molecules produced by bacteria to access iron, a key
nutrient. These compounds have highly diverse chemical structures, with various chelating …
nutrient. These compounds have highly diverse chemical structures, with various chelating …
Mining microbial genomes for new natural products and biosynthetic pathways
GL Challis - Microbiology, 2008 - microbiologyresearch.org
Analyses of microbial genome sequences have revealed numerous examples of 'cryptic'or
'orphan'biosynthetic gene clusters, with the potential to direct the production of novel …
'orphan'biosynthetic gene clusters, with the potential to direct the production of novel …
Structural biology of nonribosomal peptide synthetases
The nonribosomal peptide synthetases are modular enzymes that catalyze synthesis of
important peptide products from a variety of standard and non-proteinogenic amino acid …
important peptide products from a variety of standard and non-proteinogenic amino acid …
Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents
J Ma, H Huang, Y Xie, Z Liu, J Zhao, C Zhang… - Nature …, 2017 - nature.com
Tuberculosis remains one of the world's deadliest communicable diseases, novel anti-
tuberculosis agents are urgently needed due to severe drug resistance and the co-epidemic …
tuberculosis agents are urgently needed due to severe drug resistance and the co-epidemic …
Recent advances in siderophore biosynthesis
SM Barry, GL Challis - Current Opinion in Chemical Biology, 2009 - Elsevier
The biosynthesis of the microbial small molecule iron scavengers known as siderophores
has been of interest since their discovery in the middle of the past century. Two main …
has been of interest since their discovery in the middle of the past century. Two main …