Polychlorinated biphenyls (PCBs) in the environment: occupational and exposure events, effects on human health and fertility

L Montano, C Pironti, G Pinto, M Ricciardi, A Buono… - Toxics, 2022 - mdpi.com
In the last decade or so, polychlorinated biphenyls (PCBs) garnered renewed attention in
the scientific community due to new evidence pointing at their continued presence in the …

Neurotoxicity of polychlorinated biphenyls and related organohalogens

IN Pessah, PJ Lein, RF Seegal, SK Sagiv - Acta neuropathologica, 2019 - Springer
Halogenated organic compounds are pervasive in natural and built environments. Despite
restrictions on the production of many of these compounds in most parts of the world through …

Using the Morris water maze to assess spatial learning and memory in weanling mice

CD Barnhart, D Yang, PJ Lein - PloS one, 2015 - journals.plos.org
Mouse models have been indispensable for elucidating normal and pathological processes
that influence learning and memory. A widely used method for assessing these cognitive …

Evidence implicating non-dioxin-like congeners as the key mediators of polychlorinated biphenyl (PCB) developmental neurotoxicity

C Klocke, PJ Lein - International journal of molecular sciences, 2020 - mdpi.com
Despite being banned from production for decades, polychlorinated biphenyls (PCBs)
continue to pose a significant risk to human health. This is due to not only the continued …

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection …

M Aschner, S Ceccatelli, M Daneshian, E Fritsche… - Altex, 2016 - pmc.ncbi.nlm.nih.gov
There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard
posed by industrial and environmental chemicals. New testing approaches will most likely …

Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity

IN Pessah, G Cherednichenko, PJ Lein - Pharmacology & therapeutics, 2010 - Elsevier
Chronic low-level polychlorinated biphenyl (PCB) exposures remain a significant public
health concern since results from epidemiological studies indicate that PCB burden is …

DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?

KP Keil, PJ Lein - Environmental epigenetics, 2016 - academic.oup.com
There is now compelling evidence that gene by environment interactions are important in
the etiology of autism spectrum disorders (ASDs). However, the mechanisms by which …

Antipurinergic therapy corrects the autism-like features in the poly (IC) mouse model

RK Naviaux, Z Zolkipli, L Wang, T Nakayama… - PloS one, 2013 - journals.plos.org
Background Autism spectrum disorders (ASDs) are caused by both genetic and
environmental factors. Mitochondria act to connect genes and environment by regulating …

Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants

AK Krug, NV Balmer, F Matt, F Schönenberger… - Archives of …, 2013 - Springer
Organ-specific in vitro toxicity assays are often highly sensitive, but they lack specificity. We
evaluated here examples of assay features that can affect test specificity, and some general …

Assessment of polychlorinated biphenyls and their hydroxylated metabolites in postmortem human brain samples: age and brain region differences

X Li, MM Hefti, RF Marek, KC Hornbuckle… - … science & technology, 2022 - ACS Publications
Exposure to polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-
PCBs) has been implicated in neurodevelopmental disorders. However, the distribution of …