Polychlorinated biphenyls (PCBs) in the environment: occupational and exposure events, effects on human health and fertility
In the last decade or so, polychlorinated biphenyls (PCBs) garnered renewed attention in
the scientific community due to new evidence pointing at their continued presence in the …
the scientific community due to new evidence pointing at their continued presence in the …
Neurotoxicity of polychlorinated biphenyls and related organohalogens
Halogenated organic compounds are pervasive in natural and built environments. Despite
restrictions on the production of many of these compounds in most parts of the world through …
restrictions on the production of many of these compounds in most parts of the world through …
Using the Morris water maze to assess spatial learning and memory in weanling mice
CD Barnhart, D Yang, PJ Lein - PloS one, 2015 - journals.plos.org
Mouse models have been indispensable for elucidating normal and pathological processes
that influence learning and memory. A widely used method for assessing these cognitive …
that influence learning and memory. A widely used method for assessing these cognitive …
Evidence implicating non-dioxin-like congeners as the key mediators of polychlorinated biphenyl (PCB) developmental neurotoxicity
Despite being banned from production for decades, polychlorinated biphenyls (PCBs)
continue to pose a significant risk to human health. This is due to not only the continued …
continue to pose a significant risk to human health. This is due to not only the continued …
Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection …
There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard
posed by industrial and environmental chemicals. New testing approaches will most likely …
posed by industrial and environmental chemicals. New testing approaches will most likely …
Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity
Chronic low-level polychlorinated biphenyl (PCB) exposures remain a significant public
health concern since results from epidemiological studies indicate that PCB burden is …
health concern since results from epidemiological studies indicate that PCB burden is …
DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?
There is now compelling evidence that gene by environment interactions are important in
the etiology of autism spectrum disorders (ASDs). However, the mechanisms by which …
the etiology of autism spectrum disorders (ASDs). However, the mechanisms by which …
Antipurinergic therapy corrects the autism-like features in the poly (IC) mouse model
RK Naviaux, Z Zolkipli, L Wang, T Nakayama… - PloS one, 2013 - journals.plos.org
Background Autism spectrum disorders (ASDs) are caused by both genetic and
environmental factors. Mitochondria act to connect genes and environment by regulating …
environmental factors. Mitochondria act to connect genes and environment by regulating …
Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants
AK Krug, NV Balmer, F Matt, F Schönenberger… - Archives of …, 2013 - Springer
Organ-specific in vitro toxicity assays are often highly sensitive, but they lack specificity. We
evaluated here examples of assay features that can affect test specificity, and some general …
evaluated here examples of assay features that can affect test specificity, and some general …
Assessment of polychlorinated biphenyls and their hydroxylated metabolites in postmortem human brain samples: age and brain region differences
Exposure to polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-
PCBs) has been implicated in neurodevelopmental disorders. However, the distribution of …
PCBs) has been implicated in neurodevelopmental disorders. However, the distribution of …