T cells play a crucial role in controlling and driving the immune response with their ability to
discriminate peptides derived from healthy as well as pathogenic proteins. In this review, we …

High‐resolution experimental structural determination of protein–protein interactions has led
to valuable mechanistic insights, yet due to the massive number of interactions and …

The cellular immune system, which is a critical component of human immunity, uses T cell
receptors (TCRs) to recognize antigenic proteins in the form of peptides presented by major …

B cell receptors (BCRs) and T cell receptors (TCRs) make up an essential network of
defense molecules that, collectively, can distinguish self from non-self and facilitate …

H3K27M, a driver mutation with T and B cell neoepitope characteristics, defines an
aggressive subtype of diffuse glioma with poor survival. We functionally dissect the immune …

The adaptive immune system uses two main types of antigen receptors: T-cell receptors
(TCRs) and antibodies. While both proteins share a globally similar β-sandwich architecture …

T-cell-based immunotherapies hold tremendous potential in the fight against cancer, thanks
to their capacity to specifically targeting diseased cells. Nevertheless, this potential has been …

The physical interaction between the T cell receptor (TCR) and its cognate antigen causes T
cells to activate and participate in the immune response. Understanding this physical …

Cellular immunity relies on the ability of a T-cell receptor (TCR) to recognize a peptide (p)
presented by a class I major histocompatibility complex (MHC) receptor on the surface of a …

In recent years, the advances in high-throughput and deep sequencing have generated a
diverse amount of adaptive immune repertoire data. This surge in data has seen a …