Astrocytes play key roles in the regulation of brain energy metabolism, which has a major
impact on brain functions, including memory, neuroprotection, resistance to oxidative stress …

Intense sociality has been a catalyst for human culture and civilization, and our social
relationships at a personal level play a pivotal role in our health and well-being. These …

A hallmark of nervous system aging is a decline of white matter volume and function, but the
underlying mechanisms leading to white matter pathology are unknown. In the present …

Aging results in gray and white matter degeneration, but the specific microglial responses
are unknown. Using single-cell RNA sequencing from white and gray matter separately, we …

Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

Adolescence is the phase of life stretching between childhood and adulthood, and its
definition has long posed a conundrum. Adolescence encompasses elements of biological …

Attention deficit hyperactivity disorder (ADHD) is among the most frequent disorders within
child and adolescent psychiatry, with a prevalence of over 5%. Nosological systems, such as …

Background & Aims Based largely on results from preclinical studies, the concept of a brain
gut microbiome axis has been established, mediating bidirectional communication between …

Age-associated disease and disability are placing a growing burden on society. However,
ageing does not affect people uniformly. Hence, markers of the underlying biological ageing …

Brain cells normally respond adaptively to bioenergetic challenges resulting from ongoing
activity in neuronal circuits, and from environmental energetic stressors such as food …