Apolipoprotein E (ApoE) is of great interest due to its role as a cholesterol/lipid transporter in
the central nervous system (CNS) and as the most influential genetic risk factor for Alzheimer …

Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older
people, which severely impairs patients' quality of life. In the recent years, the number of …

Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic
contents to lysosomes for degradation. Genetic studies have revealed extensive links …

Autophagy is a lysosomal degradative process used to recycle obsolete cellular constituents
and eliminate damaged organelles and protein aggregates. These substrates reach …

Autophagy is a major protein turnover pathway by which cellular components are delivered
into the lysosomes for degradation and recycling. This intracellular process is able to …

Autophagy and endocytosis deliver unneeded cellular materials to lysosomes for
degradation. Beyond processing cellular waste, lysosomes release metabolites and ions …

Abnormalities of the endosomal–lysosomal network (ELN) are a signature feature of
Alzheimer's disease (AD). These include the earliest known cytopathology that is specific to …

Autophagy is an essential degradation pathway in clearing abnormal protein aggregates in
mammalian cells and is responsible for protein homeostasis and neuronal health. Several …

Deficiency in cerebral amyloid β-protein (Aβ) clearance is implicated in the pathogenesis of
the common late-onset forms of Alzheimer's disease (AD). Accumulation of misfolded Aβ in …

Alzheimer's disease (AD) is the most common type of dementia which characterized by a
progressive loss of memory and cognitive function due to degeneration of synapses and …