Vascular endothelium maintains vascular homeostasis through liberating a spectrum of
vasoactive molecules, both protective and harmful regulators of vascular tone, structural …

Autophagy is a dynamic circulatory system that occurs in all eukaryotic cells. Cytoplasmic
material is transported to lysosomes for degradation and recovery through autophagy. This …

Background: Vascular endothelial cells are critical for maintaining blood pressure (BP) by
releasing biologically active molecules, such as nitric oxide. A non-endothelial cell resident …

Background: The Hippo-YAP (yes-associated protein) signaling pathway is modulated in
response to various environmental cues. Activation of YAP in vascular smooth muscle cells …

Heart disease, including coronary artery disease, myocardial infarction, heart failure, cardiac
hypertrophy, and cardiomyopathies, is the leading causes of death worldwide. The Hippo …

BACKGROUND: Hyperglycemia—a symptom that characterizes diabetes—is highly
associated with atherothrombotic complications. However, the underlying mechanism by …

Lenvatinib, a multitarget tyrosine kinase inhibitor (TKI), increases the incidence of severe
hypertension and thus the incidence of cardiovascular complications. Inhibition of …

Clinically used inhibitors of mammalian target of rapamycin (mTOR) negatively impacts
endothelial-dependent vasodilatation (EDD) through unidentified mechanisms. Here we …

Background: Metabolic syndrome is related to cardiovascular diseases, which is attributed in
part, to arterial stiffness; however, the mechanisms remain unclear. The present study aimed …

We used N-ethyl-N-nitrosurea–induced germline mutagenesis combined with automated
meiotic mapping to identify specific systolic blood pressure (SBP) and heart rate (HR) …