Cells and organisms must coordinate their metabolic activity with changes in their
environment to ensure their growth only when conditions are favourable. In order to maintain …

Mammalian target of rapamycin (mTOR) is a highly conserved Serine/Threonine (Ser/Thr)
protein kinase, which belongs to phosphatidylinositol-3-kinase-related kinase (PIKK) protein …

In my PNAS Inaugural Article, I describe the development of the mTOR field, starting with
efforts to understand the mechanism of action of the drug rapamycin, which∼ 25 y ago led to …

The class I phosphoinositide 3-kinase (PI3K)–mechanistic target of rapamycin (mTOR)
complex 1 (mTORC1) signaling network directs cellular metabolism and growth. Activation …

The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite
for life. Nutrient scarcity is a selective pressure that has shaped the evolution of most cellular …

The protein kinase complex mechanistic target of rapamycin complex 1 (mTORC1) serves
as a key conduit between growth signals and the metabolic processes underlying cell …

The mechanistic target of rapamycin (mTOR), master regulator of cellular metabolism, exists
in two distinct complexes: mTOR complex 1 and mTOR complex 2 (mTORC1 and 2) …

Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of
insulin resistance. The term insulin resistance is very wide and could affect different proteins …

The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular
and organismal growth, and hyperactivation of this pathway is implicated in the …

The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein
kinase, controls cell growth in response to nutrients and growth factors and is frequently …