Stress is a primary risk factor for several neuropsychiatric disorders. Evidence from
preclinical models and clinical studies of depression have revealed an array of structural …

Importance Depression in older adults is a common psychiatric disorder affecting their
health-related quality of life. Major depression occurs in 2% of adults aged 55 years or older …

Major depressive disorder (MDD) is a leading cause of disease burden worldwide. While the
incidence, symptoms and treatment of MDD all point toward major sex differences, the …

Major life stressors, especially those involving interpersonal stress and social rejection, are
among the strongest proximal risk factors for depression. In this review, we propose a …

Depression is an episodic form of mental illness characterized by mood state transitions with
poorly understood neurobiological mechanisms. Antidepressants reverse the effects of …

Stressors are imminent or perceived challenges to homeostasis. The stress response is an
innate, stereotypic, adaptive response to stressors that has evolved in the service of …

A deeper understanding of the pathomechanisms leading to stress-related psychiatric
disorders is important for the development of more efficient preventive and therapeutic …

Neuropathic pain arises as a consequence of a lesion or disease affecting the
somatosensory system. It is generally chronic and challenging to treat. The recommended …

Neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF) and other
members of the neurotrophin family, are central mediators of the activity-dependent plasticity …

Neuropathic and inflammatory pain promote a large number of persisting adaptations at the
cellular and molecular level, allowing even transient tissue or nerve damage to elicit …