The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders
Stress is a primary risk factor for several neuropsychiatric disorders. Evidence from
preclinical models and clinical studies of depression have revealed an array of structural …
preclinical models and clinical studies of depression have revealed an array of structural …
Management of depression in older adults: a review
RM Kok, CF Reynolds - Jama, 2017 - jamanetwork.com
Importance Depression in older adults is a common psychiatric disorder affecting their
health-related quality of life. Major depression occurs in 2% of adults aged 55 years or older …
health-related quality of life. Major depression occurs in 2% of adults aged 55 years or older …
Sex-specific transcriptional signatures in human depression
Major depressive disorder (MDD) is a leading cause of disease burden worldwide. While the
incidence, symptoms and treatment of MDD all point toward major sex differences, the …
incidence, symptoms and treatment of MDD all point toward major sex differences, the …
From stress to inflammation and major depressive disorder: a social signal transduction theory of depression.
GM Slavich, MR Irwin - Psychological bulletin, 2014 - psycnet.apa.org
Major life stressors, especially those involving interpersonal stress and social rejection, are
among the strongest proximal risk factors for depression. In this review, we propose a …
among the strongest proximal risk factors for depression. In this review, we propose a …
Synaptic mechanisms regulating mood state transitions in depression
PK Parekh, SB Johnson, C Liston - Annual Review of …, 2022 - annualreviews.org
Depression is an episodic form of mental illness characterized by mood state transitions with
poorly understood neurobiological mechanisms. Antidepressants reverse the effects of …
poorly understood neurobiological mechanisms. Antidepressants reverse the effects of …
The organization of the stress system and its dysregulation in depressive illness
PW Gold - Molecular psychiatry, 2015 - nature.com
Stressors are imminent or perceived challenges to homeostasis. The stress response is an
innate, stereotypic, adaptive response to stressors that has evolved in the service of …
innate, stereotypic, adaptive response to stressors that has evolved in the service of …
[HTML][HTML] Epigenetics of stress-related psychiatric disorders and gene× environment interactions
A deeper understanding of the pathomechanisms leading to stress-related psychiatric
disorders is important for the development of more efficient preventive and therapeutic …
disorders is important for the development of more efficient preventive and therapeutic …
Antidepressants and gabapentinoids in neuropathic pain: mechanistic insights
Neuropathic pain arises as a consequence of a lesion or disease affecting the
somatosensory system. It is generally chronic and challenging to treat. The recommended …
somatosensory system. It is generally chronic and challenging to treat. The recommended …
[HTML][HTML] Neuronal plasticity and neurotrophic factors in drug responses
Neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF) and other
members of the neurotrophin family, are central mediators of the activity-dependent plasticity …
members of the neurotrophin family, are central mediators of the activity-dependent plasticity …
Epigenetic mechanisms of chronic pain
Neuropathic and inflammatory pain promote a large number of persisting adaptations at the
cellular and molecular level, allowing even transient tissue or nerve damage to elicit …
cellular and molecular level, allowing even transient tissue or nerve damage to elicit …