With a political debate about the potential risks and benefits of cannabis use as a backdrop,
the wave of legalization and liberalization initiatives continues to spread. Four states …

The posterior cingulate cortex is a highly connected and metabolically active brain region.
Recent studies suggest it has an important cognitive role, although there is no consensus …

Despite extensive study over the past decades, available treatments for schizophrenia are
only modestly effective and cause serious metabolic and neurological side effects …

The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …

The high heterogeneity of psychiatric disorders leads to a lack of diagnostic precision.
Therefore, the search of biomarkers is a fundamental aspect in psychiatry to reach a more …

Heavy cannabis use has been frequently associated with increased rates of mental illness
and cognitive impairment, particularly amongst adolescent users. However, the …

Objectives The liberalisation of cannabis laws, the increasing availability and potency of
cannabis has renewed concern about the risk of psychosis with cannabis. Methods The …

Psychotic disorders such as schizophrenia are heterogeneous and often debilitating
conditions that contribute substantially to the global burden of disease. The introduction of …

Importance In schizophrenia, the severity of negative symptoms is a key predictor of long-
term disability. Deficient signaling through theN-methyl-D-aspartate receptor is hypothesized …

Placebo analgesia is mediated by both opioid and nonopioid mechanisms, but so far
nothing is known about the nonopioid component. Here we show that the specific CB1 …