Obesity is a complex, heritable trait influenced by the interplay of genetics, epigenetics,
metagenomics and the environment. With the increasing access to high precision diagnostic …

Leptin has key roles in the regulation of energy balance, body weight, metabolism, and
endocrine function. Leptin levels are undetectable or very low in patients with lipodystrophy …

Mutations in the gene encoding leptin (LEP) typically lead to an absence of circulating leptin
and to extreme obesity. We describe a 2-year-old boy with early-onset extreme obesity due …

Obesity and colorectal cancer (CRC) are among the leading diseases causing deaths in the
world, showing a complex multifactorial pathology. Obesity is considered a risk factor in …

Leptin protein consists of 167 amino acids, which is mainly secreted from the white adipose
tissue. This protein acts on the hypothalamic regions of the brain which control eating …

Leptin is an adipocyte-secreted hormone that has been proposed to regulate energy
homeostasis as well as metabolic, reproductive, neuroendocrine, and immune functions. In …

High levels of perceived stress and anxiety among university students are a global concern
and are known to negatively influence sleep. However, few studies have explored how …

This narrative review aims to pinpoint mental and behavioral effects of starvation, which may
be triggered by hypoleptinemia and as such may be amenable to treatment with leptin …

Leptin, a hormone released by the body to regulate energy balance by inhibiting hunger,
decreases fat storage in adipocytes. Leptin is thought to play some role in obesity and …

Leptin is an adipocyte-derived hormone involved in a myriad of physiological process,
including the control of energy balance and several neuroendocrine axes. Leptin-deficient …