Fibrosis is increasingly appreciated as a major player in adipose tissue dysfunction. In
rapidly expanding adipose tissue, pervasive hypoxia leads to an induction of HIF1α that in …

Adipose tissue constitutes an extremely active endocrine organ with a network of signaling
pathways enabling the organism to adapt to a wide range of different metabolic challenges …

Objective Individuals with obesity and type 2 diabetes differ from lean and healthy
individuals in their abundance of certain gut microbial species and microbial gene richness …

Obesity is a multifactorial disease in which environmental conditions and several genes play
an important role in the development of this disease. Obesity is associated with …

Background: Roux-en-Y gastric bypass (RYGB) surgery is one of the most efficient
procedures for treating morbid obesity and results in weight-loss and improvements in …

OBJECTIVE Fibrosis is a newly appreciated hallmark of the pathological alteration of human
white adipose tissue (WAT). We investigated the composition of subcutaneous (scWAT) and …

Ageing, like obesity, is often associated with alterations in metabolic and inflammatory
processes resulting in morbidity from diseases characterised by poor metabolic control …

Context: Macrophages accumulate in adipose tissue and possibly participate in metabolic
complications in obesity. Macrophage number varies with adipose tissue site and weight …

Type 2 diabetes mellitus (T2D) is predicted by central obesity and circulating adipokines
regulating inflammation. We hypothesized that visceral adipose tissue (VAT) in T2D …

In obesity, a paracrine loop between adipocytes and macrophages augments chronic
inflammation of adipose tissue, thereby inducing systemic insulin resistance and ectopic …